Engineering oral tissues

Details Engineering oral tissues Engineering oral tissues

1997-05-28

1999-03-23

Degen, Nancy

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

424 49, 424422, 424435, 435 695, 435374, 435378, C12N 500, C12N 502, C12N 508, C12N 1509

Patent

active

058858296

ABSTRACT:
Disclosed are methods for regenerating dental and oral tissues from viable cells using ex vivo culture on a structural matrix. The regenerated oral tissues and tissue-matrix preparations thus provided have both clinical applications in dentistry and oral medicine and are also useful in in vitro toxicity and biocompatibility testing.

REFERENCES:
patent: 4963489 (1990-10-01), Naughton et al.
patent: 5032508 (1991-07-01), Naughton et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5518915 (1996-05-01), Naughton et al.
patent: 5567612 (1996-10-01), Vacanti et al.
patent: 5624840 (1997-04-01), Naughton et al.
patent: 5759830 (1998-06-01), Vacanti et al.
patent: 5770193 (1998-06-01), Vacanti et al.
patent: 5770417 (1998-06-01), Vacanti et al.
Bohl, K. et al., "Synthetic Extracellular Matrices for Engineering Dental Pulp," Abstract distributed a Fifth World Biomaterals Congress, Toronto, Canada, May 29, 1996.
Gombotz and Pettit, "Biodegradable polymers for protein and peptide drug delivery," Bioconjugate Chem., 6:332-351, 1995.
Goshima et al., "The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells," Clin. Orthopod. Rel. Res., 269:274-283, 1991.
Green et al., "Growth of cultured human epidermal cells into multiple epithelia suitable for grafting," Proc. Natl. Acad. Sci. USA, 76:5665-5668, 1979.
Gu, et al., "Expression of genes for bone morphogenetic proteins and receptors in human dental pulp", Archives of Oral Biology, 41(10):919-23, 1996.
Hansbrough et al., "Evaluation of a biodegradable matrix containing cultured human fibroblasts as a dermal replacement beneath meshed skin grafts on athymic mice," Surgery, 4:438-446, 1992.
Hubbell, "Biomaterials in tissue engineering," Bio/Technology, 13:565-576, 1995.
Langer and Vacanti, "Tissue engineering," Science, 260:920-926, 1993.
Laurencin et al., "Use of polyphosphazenes for skeletal tissue regeneration," J. Biomed. Mater. Res., 27:963-973, 1993.
Lesot et al., "Experimental Induction of odontoblast Differentiation and Stimulation During Reparative Processes," Cells and Materials, 3:201-217, 1993.
Mikos et al., "Preparation of poly (glycolic acid) bonded fiber structures for cell attachment and transplantion," J. Biomed. Mat. Res., 27:183, 1993.
Mikos et al., "Prevascularization of porous biodegradable polymers," Biotech. bioeng., 42:716-723, 1993.
Mooney and Vacanti, "Tissue engineering using cells and synthetic polymers," Trans. Rev., 7:153-162, 1993.
Mooney et al., "Design and fabrication of biodegradable polymer devices to engineer tubular tissues," Cell Transplantation, 3:203, 1994.
Mooney et al., "Transplantation of hepatocytes using porous, biodegradable sponges," Transplan. Proc., 26(6):4025-4026, 1994.
Mooney et al., "Biodegradable Sponges for Hepatocyte Transplantation," J. Biomed. Mat. Res.,29:959-965, 1995.
Mooney et al., "Fabricating Tubular Devices From Polymers of Lactic and Glycolic Acid for Tissue Engineering," Tiss. Eng., 1:107-118, 1995.
Mooney et al., "Stabilized Polyglycolic Acid Fibre-Based Tubes for Tissue Engineering," Biomaterials, 17:115-124, 1996.
Mooney et al., "Engineering dental pulp-like tissue in vitro," Biotechnol. Prog. 12(6):865-868, 1996.
Mooney, et al., "Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes," Biotechnology and Bioengineering, 50(4):422-429, 1996.
Mooney et al., "Novel approach to fabricate porous sponges of poly(D,Llactic-co-glycolic acid) without the use of organic solvents," Biomaterials, 17(14):1417-1422, 1996.
Mooney, et. al., "Tissue engineering: Tubular tissues," In: Yearbook of Cell and Tissue Transplantion, Lanza and Chick (Ed.), pp. 275-282, 1996.
Nakashima, "Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Protieins (BMP)-2 and -4," J. Dent Res., 73:1515-1522, 1994.
Putnam, and Mooney, "Tisue engineering using synthetic extracellular matrices," Nature Medicine 2(7):824-826, 1996.
Rutherford et al, "Induction of Reparative Dentine Formation in Monkeys by Recombinant Human Osteogenic Protein-1," Archs Oral Biol., 38:571-576, 1993.
Rutherford et al., "Platelet derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys," J. Perio Res., 27:285-290, 1992.
Rutherford et al., "The Time-Course of the Induction of Reparative Dentine Formation in Monkeys by Recombinant Human Osteogenic Protein-1," Arch Oral Biol., 39:833-838, 1994.
Rutherford et al., "Transdentinal Stimulation of Reparative Dentine formation by Osteogenic Protein-1," Archs. Oral Biol., 40:681-683, 1995.
Rutherford et al., "Platelet-derived growth factor and dexamethasone combined with a collagen matrix induced regeneration of the periodontium in monkeys," J. Clin. Perio, 20:537-544, 1993.
Yannas et al., "Wound tissue can utilize a polymeric template to synthesize and functional extension of skin," Science, 215:174-176, 1981.
Yannas et al., "Synthesis and characterization of a model of extracellular matrix that induces partial regeneration of adult mammalian skin," Proc. Natl. Acad. Sci. USA, 86:933-937, 1989.
Bouvier, Joffre and Magloire, "In Vitro Mineralization of a Three-Dimensional Collagen Matrix by Human Dental pulp Cells in the Presence of Chondroitin Sulphate," Archs Oral Biol., 35(4):301-309, 1990
Rutherford et al., "Synergistic Effects of Dexamethasone on Platelet-Derived Growth Factor Mitogenesis In Vitro," Archs Oral Biol., 37(2):139-145, 1992.
Sasaki et al., "Inhibition of Wound Contraction bt Papaverine: In Vitro Analysis with a Submucosal Tissue Model," Annals of Plastic Surgery, 27(6),Dec. 1991.
Suwa et al., "Inductive Effect of Bovine Bone Morphogenetic Protein on Human Dental Pulp Tissue In Vitro," 13-Mammalian Biochem., 122:707, 1995, Abstract No. 77691w.
Ueda, Ebata, and Kaneda, "In Vitro Fabrication of Bioartificial Mucosa for Reconstruction of Oral Mucosa: Basic Research and Clinical Application," Annals of Plastic Surgery, 27(6), Dec. 1991.
International Search Report dated Sep. 29, 1997 (UMIC:019P).

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