Engineering of strong, pliable tissues

Details Engineering of strong, pliable tissues Engineering of strong, pliable tissues

2011-07-26

2011-07-26

Isabella, David (Department: 3774)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Heart valve

Flexible leaflet

C623S002100, C623S002420, C424S422000, C424S423000, C424S424000, C424S425000, C424S426000, C435S395000, C435S398000

Reissue Patent

active

RE042575

ABSTRACT:
It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.

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