Engineering of strong, pliable tissues

Details Engineering of strong, pliable tissues Engineering of strong, pliable tissues

1995-05-19

1999-01-05

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

A61F 202

Patent

active

058556109

ABSTRACT:
It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.

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