Engineering of electrostatic interactions at metal ion binding s

Details Engineering of electrostatic interactions at metal ion binding s Engineering of electrostatic interactions at metal ion binding s

1990-10-19

1993-11-09

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435222, 25217412, C12N 954, C12N 956, C11D 940

Patent

active

052602079

ABSTRACT:
The present invention provides a method for redesigning proteins to increase the stability of the protein by altering amino acid residue(s) that are in close proximity to the protein's metal ion binding site(s). Further, the invention is directed to proteins that have been redesigned to have enhanced stability according to the methods of this invention.

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