Engineered peptide synthetases and their use for the non-ribosom

Details Engineered peptide synthetases and their use for the non-ribosom Engineered peptide synthetases and their use for the non-ribosom

1996-06-26

1998-08-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 4352523, 4353201, 536 232, 536 234, C12P 2106, C12P 2104, C12N 120, C07H 2104

Patent

active

057957380

ABSTRACT:
The present invention relates to the construction of functional engineered peptide synthetases capable of displaying a correct activity and their use for the non-ribosomal production of modified peptides.

REFERENCES:
Stachelhaus et al. (Jul. 7, 1995) Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains, Science 269:69-72.
van Liempt et al. (Sep. 1991) Principles of the Molecular Construction of Multienzyme Templates for Peptide Biosynthesis in Integrated Reaction Sequences, Biomed. Biochim. Acta 50 (10/11): S256-S259.
Wiseman, A. (Feb. 1993) Designer Enzyme and Cell Applications in Industry and in Environmental Monitoring, J. Chem. Tech. Biotechnol. 56: 3-13.

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