Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-12-16
1997-09-02
Cain, Edward J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3700, A61K 3855
Patent
active
056631430
ABSTRACT:
Certain Kunitz domain derived proteins which bind and inhibit human neutrophil elastase with a K.sub.i of less than 10 picomolar are described.
REFERENCES:
patent: 5407915 (1995-04-01), Fritz et al.
patent: 5409895 (1995-04-01), Morishita et al.
Keystone Symposium on Structural and Molecular Biology of Protease Function and Inhibition, Santa Fe, New Mexico, USA, Mar. 5-12, 1994, Journal of Cellular Biochemistry Supplement O (18d). 1994. 157. Markland W et al: "Selection for protease inhibitors using the bacteriophage-display technology".
Proc Natl Acad Sci USA 89 (6). 1992. 2429-2433. Roberts B L et al: "Directed Evolution of a Protein Selection of Potent Neutrophil Elastase Inhibitors Displayed on M13 Fusion Phage".
Biochemistry, vol. 29, No. 33, 21 Aug. 1990, pp. 7539-7546, Broze Jr G J et al: "Regulation of Coagulation by a Multivalent Kunitz-Type Inhibitor".
Guterman Sonia Kosow
Kent Rachel Baribault
Ladner Robert Charles
Ley Arthur Charles
Markland William
Cain Edward J.
Cooper Iver P.
Dyax Corp.
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