Engineered antigen presenting cells and methods for their use

Details Engineered antigen presenting cells and methods for their use Engineered antigen presenting cells and methods for their use

1997-07-03

1999-10-05

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435325, 424 9321, C12N 510, A61K 4505

Patent

active

059623209

ABSTRACT:
Autologous, heterologous or xenogeneic primary cells or cell lines are genetically modified ex vivo to render the cells capable of processing and presenting selected antigens to cells of the immune system of a subject, and to express different HLA molecules for matching to the HLA specificity of the subject. The cells are also modified to express immunoregulatory molecules for directing the immune response of the subject. The cells and cell lines are used in methods to treat infectious diseases or cancer, or to prevent infectious disease by inoculation into a host to activate T cells and induce an antigen-specific immune response, and in assays of the cytolytic activity of a subject's T cells. The cells can also be used to suppress an unwanted immune response of a subject to a selected antigen where the cells lack expression of a costimulation molecule needed for T cell activation.

REFERENCES:
patent: 5716826 (1998-02-01), Gruber et al.
patent: 5738852 (1998-04-01), Robinson et al.
Townsend et al., Science 259:368-370 (1993).
Chen et al., Cell 71:1093-1102 (1992).
Boussiotis et al., Current Opinion in Immunology 6:797-807 (1994).

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