Energetically-controlled delivery of biologically active...

Details Energetically-controlled delivery of biologically active... Energetically-controlled delivery of biologically active...

2006-09-05

2006-09-05

Snow, Bruce (Department: 3738)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Drug delivery

C623S001440, C623S023730, C623S023750, C424S424000, C424S426000

Reexamination Certificate

active

07101394

ABSTRACT:
A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.

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