Enediyne derivatives useful for the synthesis of conjugates of m

Details Enediyne derivatives useful for the synthesis of conjugates of m Enediyne derivatives useful for the synthesis of conjugates of m

1995-06-05

1998-04-14

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 5, 514 12, 514 53, 514 56, 514 61, 4241781, 536 168, 536 175, A01N 4304, A01N 4500, A61K 3900, C12P 1944

Patent

active

057391165

ABSTRACT:
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

REFERENCES:
patent: 5053394 (1991-10-01), Ellestad et al.

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