Endowing lymphocytes with antibody specificity

Details Endowing lymphocytes with antibody specificity Endowing lymphocytes with antibody specificity

1995-06-07

1999-06-15

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

435 697, 435326, 435330, 435339, 435340, 435344, 435346, 435372, 424 9321, 4241841, 4241341, 4241441, 4241851, 536 2353, 5303873, C12N 1513, C07H 2104, C07K 1646

Patent

active

059121726

ABSTRACT:
There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

REFERENCES:
Berke et al (1981). "T Lymphocyte-Mediated Cytolysis. I. A Common Mechanism for Target Recognition in Specific and Lectin-Dependent Cytolysis", J. Immunol., 127:776-781.
Berke et al (1981). "T Lymphocyte-Mediated Cytolysis. II. Role of Target Cell Histo-compatibility Antigens in Recognition and Lysis", J. Immunol., 127:782-787.
Berke et al (1982). "T Lymphocyte-Mediated Cytolysis. I. The Mechanism of CTL-Mediated Cytolysis", in Adv. Exptl. Biol. Med., 146:57-68, eds. Clark, W.R. et al, Plenum Press, New York.
Berke et al (1983). "Cytotoxic T-Lymphocytes: How Do They Function?", Immunological Rev., 72: 5-42.
Bretscher, P. (1992). "The Two-Signal Model of Lymphocyte Activation Twenty-One Years Later", Immunolo. Today 13(2):74-76.
Clark et al (1982). "T Lymphocyte-Mediated Cytolysis. II. Lytic vs. Nonlytic Interactions of T Lymphocytes", in Adv. Exptol. Biol. Med., 146:69-79, eds. Clark W.R. et al, Plenum Press, N.Y.
Cline, J. (1986). "Gene Therapy: Current Status and Future Directions", Schweizerische Medizinische Wochenschrift, 116(43):1459-1464.
Goverman et al (1990). "Chimeric Immunoglobulin-T Cell Receptor Proteins Form Functional Receptors: Implications for T Cell Receptor Complex Formation and Activation", Cell, 60(6):929-939.
Henkart, P.A. (1994). "Lymphocyte-Mediated Cytotoxicity: Two Pathways and Multiple Effector Molecules", Immunity, 1:343-346.
Jenkins et al (1987). "T-Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State", Immunol. Rev., 95:113-135.
Jenkins et al (1987). "Molecular Events in the Induction of a Nonresponsive State in Interleukin 2-Producing Helper T-Lymphocyte Clone", Proc. Natl. Acad. Sci. (USA), 84:5409-5413.
Jenkins, M.K. (1992). "The Role of Cell Division in the Induction of Clonal Anergy", Immunology Today, 13(2):69-73.
June et al (1994). "The B7 and CD28 Receptor Families", Immunology Today, 15:321-331.
Kaufmann et al (1981). "Cytotoxic T Lymphocyte hybridomas which medicate specific tumor-cell lysis in vitro", Proc. Natl. Acad. Sci. USA, 78:2502-2506.
Kuwana et al (1987). "Expression of Chimeric Receptor Composed of Immunoglobulin-Derived V Regions and T-Cell Receptor-Derived C Regions", Biochem. Biophys. Res. Commun., 149(3):960-968.
Ostergaard et al (1987). "The Role of Ca.sup.2+ in Activation of Mature Cytotoxic T Lymphocytes for Lysis", J. Immunol., 139(11):3573-3579.
Rouvier et al (1993). "Fas Involvement in Ca.sup.2+ -Indendent T Cell-Mediated Cytotoxicity", J. Exp. Med., 177:195-200.
Sambhara et al (1991). "Programmed Cell Death of T Cells Signaled by the T Cell Receptor and the .alpha..sub.3 Domain of Class I MHC", Science, 252:1424-1427.
Schwartz, R.H. (1992). "Costimulation of T Lymphocytes: The Role of CD28, CTLA-4, and B7/BB1 in Interleukin-2 Production and Immunotherapy", Cell, 2:1065-1068.
Tirosh et al (1985). "Immune Cytolysis Viewed as a Stimulatory Process of the Target", in Mechanisms of Cell-Mediated Cytotoxicity, eds. Henkart et al, Plenum Press, New York, pp. 473-492.
Trenn et al (1987). "Exocytosis of Cytolytic Granules May Not Be Required for Target Cell Lysis by Cytotoxic T-Lymphocytes", Nature, 330:72-74.
Truneh et al (1985). "Early steps of Lymphocyte activation . . .", Nature, 313:318-320.
Wacholtz et al (1993). "Anti-CD3-Stiulated Ca.sup.2+ Signal in Individual Human Peripheral T Cells", J. Immunol., 150:5338-5349.
Yague et al (1985). "The T-cell Receptor: The Alpha and Beta Chains Define Idiotype, and Antigen and MHC Specificity", Cell, 42:81-87.
Dembic, et al (1986). "Transfer of specificity by murine .alpha. and .beta. T-cell receptor genes", Nature, 320:232-238.
Denny et al. Nature 320:549, Apr. 1986.
Ohashi et al., Nature 316:606-609, Aug. 1985.
Kuwana et al., Biochem. Biophys. Research, Dec. 1987.
Saito et al. Nature 329:256-259, Sep. 1987.
Gascoigne et al. PNAS 84:2936-2940, May 1987.
Mariuzza et al. J. Biol. Chem. 264(13):7310-7316, May 1989.
Kimball, J.W. (1986). Introduction to Immunology, Second Edition, Macmillan Publishing Company, New York, pp. 9-10.
Lichtenheld et al (1988). "Structure and function of human perforin", Nature, vol. 335:448-451.

Affiliated with

Also associated with

Rating

Endowing lymphocytes with antibody specificity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endowing lymphocytes with antibody specificity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endowing lymphocytes with antibody specificity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-402138