Endowing lymphocytes with antibody specificity

Details Endowing lymphocytes with antibody specificity Endowing lymphocytes with antibody specificity

1993-05-04

1999-05-25

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

5303873, 536 2353, 435 697, 435326, 435330, 435339, 435340, 435342, 435344, 435372, 424 9321, 4241341, 4241441, 4241841, C12N 1513, C07H 2104, C07K 1646

Patent

active

059069368

ABSTRACT:
There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example, for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

REFERENCES:
Gross et al. Transplantation Proceedings 21(1):127-130 Feb. 1989.
Berke, G. (1991). "Lymphocyte-triggered internal target disintegration", Immunology Today, 12(11):396-399.
Kraehenbuehl et al (1991). "Perforin-induced pore formation", Immunology Today, 12(11):399-403.
Mariuzza et al (1989). "Secretion of a Homodimeric V.sub..alpha. C.sub..kappa. T-cell Receptor-Immunoglobulin Chimeric Protein", The Journal of Biological Chemistry, 264(13):7310-7316.
Ohashi et al (1985). "Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer", Nature, 361:606-609.
Saito et al (1987). "Predictable acquisition of a new MHG recognition specificity following expression of a transfected T-cell receptor .beta. -chain gene", Nature, 329:256-259.
Dembic, et al (1986). "Transfer of specificity by murine .alpha. and .beta. T-cell receptor genes", Nature, 320:232-238.
Linch, et al (1987). "Signal Transduction in Human T Lymphocytes", Immunological Reviews, 95: 137-159.
Maloney, et al (1985). "Monoclonal Anti-Idiotype Antibodies Against the Murine B Cell Lymphoma 38C13: Characterization and Use as Probes for the Biology of the Tumor In Vivo and In Vitro", Hybridoma, 4(3):191-209.
Ochi et al (1983). "Functional immunoglobulin M production after transfection of cloned immuno-globulin heavy and light chain genes into lymphoid cells", Proc.Natl.Acad.Sci.USA, 80:6351-6355.
Wagner, et al (1982). "Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses", J. Exp. Med., 155:1876-1881.
Weiss, et al (1986). "The Role of the T3/Antigen Receptor Complex in T-Cell Activation", Ann. Rev. Immunol., 4:593-619.
Willingham, et al (1987). "Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model", Proc. Natl. Acad. Sci. USA, 84:2474-2478.
Bell (1989). The polymerase chain reaction. Immunol. Today, 10, pp. 351-355.
Felgner et al (1987). "Lipofectin: A highly efficient, lipid mediated DNA transfection procedure", Proc. Natl. Acad. Sci (USA), 84:7413.
Potter et al (1984). "Enhancer dependent expression of human x immunoglobulin genes introduced into mouse pre B lymphocytes by electroporation", Proc. Natl. Acad. Sci. (USA), 81:7161.
Gascoigne et al, PNAS 84:2936-2940, 1987 Kimball in Intro to Immunol. 2.sup.nd ed., pp. 9-10, 1983.
Gross et al (1989). "Functional expression of a chimeric T cell receptor with an antibody binding site", In Kaplan et al (eds) "Cellular Basis of Immune Modulation", New York: Alan R. Liss, p. 97.
Gross et al (1989). "Expression of immunoglobulin/T cell chimeric molecules as functional receptors with antibody-type specificity", Proc. Natl. Acad. Sci. (USA), 86:10024.
Kasid et al (1990). "Human gene transfer: Characterizatio of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man", Proc. Natl. Acad. Sci. (USA), 87:473.
Kaufmann et al (1981). "Cytotoxic T lymphocyte hybridomas which mediate specific tumor-cell lysis in vitro", Proc. Natl. Acad. Sci, USA, 78:2502-2506.
Mullis et al (1987). "Specific synthesis of DNA in vitro via a polymerase-catalysed chain reaction", Method Enzymol., 155:335-350.
Orlandi et al (1989). "Cloning immunoglobulin in variable domains for expression by the polymerase chain reaction", Proc. Natl. Acad. Sci. (USA), 86:3833-3837.
Puri et al (1986). "Antigen-1A interaction and the proteolytic processing of antigen: The structure of the antigen determines its restriction to the A or E molecule of the MMC", Eur. J. Immunol., 16:1093.
Schmitt-Verhulst et al (1978). "H-2-Restricted Cytotoxic Effectors Generated in vitro by the Addition of Trinitrophenyl-Conjugated Soluble Proteins", J. Exp. Med., 147:352-368.
Staerz et al (1985). "Hybrid antibodies can target sites for attack by T Cells", Nature, 314:628.
Berke et al (1981). "T Lymphocyte-Mediated Cytolysis. I. A Common Mechanism for Target Recognition in Specific and Lectin-Dependent Cytolysis", J. Immunol., 127:776-781.
Berke et al (1981). "T Lymphocyte-Mediated Cytolysis. II. Role of Target Cell Histo-compatibility Antigens in Recognition and Lysis", J. Immunol., 127:782-787.
Berke et al (1982). "T Lymphocyte-Mediated Cytolysis. I. The Mechanism of CTL-Mediated Cytolysis", in Adv. Exptl. Biol. Med., 146:57-68, eds. Clark, W.R. et al, Plenum Press, New York.
Berke et al (1983). "Cytotoxic T-Lymphocytes: How Do They Function?", Immunological Rev., 72: 5-42.
Clark et al (1982). "T Lymphocyte-Mediated Cytolysis. II. Lytic vs. Nonlytic Interactions of T Lymphocytes", in Adv. Exptol. Biol. Med., 146:69-79, eds. Clark W.R. et al, Plenum Press, N.Y.
Wacholtz et al (1993). Anti-CD3-Stiulated Ca.sup.2+ Signal in Individual Human Peripheral T J. Immunol., 150:5338-5349.
Young, et al (1987). "A Calcium- and Perforin-Independent Pathway of Killing Mediated by Cytolytic Lymphocytes", J. Exp. Med., 166:1894-1899.
Sambhara et al (1991). "Programmed Cell Death of T Cells Signaled by the T Cell Receptor and the a.sub.3 Domain of Class I MHC", Science, 252:1424-1427.
Tirosh et al (1985). "Immune Cytolysis Viewed as a Stimulatory Process of the Target", in Mechanisms of Cell-Mediated Cytotoxicity, eds. Henkart et al, Plenum Press, New York, pp. 473-492.
Bretscher, P. (1992). "The Two-Signal Model of Lymphocyte Activation Twenty-One Years Later", Immunolo. Today, 13(2):74-76.
Henkart, P.A. (1994). "Lymphocyte-Mediated Cytotoxicity: Two Pathways and Multiple Effector Molecules", Immunity, 1:343-346.
Jenkins et al (1987). "T-Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State", Immunol. Rev., 95:113-135.
Jenkins et al (1987). "Molecular Events in the Induction of a Nonresponsive State in Interleukin 2-Producing Helper T-Lymphocyte Clone", Proc. Natl. Acad. Sci. (USA), 84:5409-5413.
Jenkins, M.K. (1992). "The Role of Cell Division in the Induction of Clonal Anergy", Immunology Today, 13(2):69-73.
June et al (1994). "The B7 and CD28 Receptor Families", Immunology Today, 15:321-331.
Ostergaard et al (1987). "The Role of Ca.sup.2+ in Activation of Mature Cytotoxic T Lymphocytes for Lysis", J. Immunol., 139(11):3573-3579.
Romeo et al (1992). "Sequence Requirements for Induction of Cytolysis by the T Cell Antigen/Fc Receptor .zeta. Chain", Cell, 68:889-897.
Rouvier et al (1993). "Fas Involvement in Ca.sup.2+ -Indendent T Cell-Mediated Cytotoxicity", J. Exp. Med., 177:195-200.
Rudd et al (1994). "Two-Step TCR .zeta. CD3-CD4 and CD28 Signaling in T Cells: SH2/SH3 Domains, Protein-Tyrosine and Lipid Kinases", Immunology Today, 15:225-234.
Schwartz, R.H. (1990). "A Cell Culture Model for T-Lymphocyte Clonal Anergy", Science, 248:1349-1356.
Schwartz, R.H. (1992). "Costimulation of T Lymphocytes: The Role of CD28, CTLA-4, and B7/BB1 in Interleukin-2 Production and Immunotherapy", Cell, 2:1065-1068.
Tirosh et al (1985). "T-Lymphocytes-Mediated Cytolysis as an Excitatory Process of the Target", Cell. Immunol., 95:113-123.
Trenn et al (1987). "Exocytosis of Cytolytic Granules May Not Be Required for Target Cell Lysis by Cytotoxic T-Lymphocytes", Nature, 330:72-74.
Truneh et al, Nature 313:318-320 (1985) Early Steps of Lymphocyte Activation . . .
Li

Affiliated with

Also associated with

Rating

Endowing lymphocytes with antibody specificity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endowing lymphocytes with antibody specificity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endowing lymphocytes with antibody specificity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-401098