Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-06-07
1997-07-15
Richter, Johann
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C12Q 134
Patent
active
056482302
ABSTRACT:
An endotoxin stabilizing agent is provided, which is useful in order to maintain the endotoxin activity of a specimen or a reference standard in a stable state for a prolonged period of time and to prepare an endotoxin reference standard having a reduced intervial variation, being stable for a long time in the form of, in particular, a solution and withstanding repeated use. An endotoxin composition comprising the above-mentioned endotoxin stabilizing agent and endotoxin and a method for assaying endotoxin by using the same are also provided. The endotoxin stabilizing agent comprises: (1) at least one substance selected from the group consisting of aminoalcohols, polyhydric alcohols, nonionic surfactants, polysucroses and chelating agents; (2) at least aminoalcohol and polyhydric alcohol; (3) with the polyhydric alcohol being preferably glycerol or its derivative; (4) polyethylene glycol as an effective ingredient in addition to the components (1) to (3); or (5) at least polysucrose, and an alkaline earth metal salt and/or polyethylene glycol as an effective ingredient. The endotoxin composition comprises the above-identified endotoxin stabilizing agent. The method for assaying endotoxin comprises adding the above-described endotoxin stabilizing agent to a specimen to thereby stabilize the activity of endotoxin in the specimen.
REFERENCES:
"Laboratory of Reference Reagents", DPQC/CBER/FDA Product Informatuon Circular, May 23, 1995.
Aketagawa Jun
Oda Toshio
Tamura Hiroshi
Tanaka Shigenori
Richter Johann
Sackey Ebenezer
Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)
LandOfFree
Endotoxin stabilizing agent, endotoxin composition and method fo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Endotoxin stabilizing agent, endotoxin composition and method fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endotoxin stabilizing agent, endotoxin composition and method fo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1491711