Liquid purification or separation – Processes – Ion exchange or selective sorption
Patent
1986-02-21
1987-04-28
Cintins, Ivars
Liquid purification or separation
Processes
Ion exchange or selective sorption
210691, 210927, B01D 1500
Patent
active
046612602
ABSTRACT:
The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.
The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.
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Watanabe et al: "Immobilization of hen egg--white lysozyme and polypeptide antibiotic polymyxin B for producing antibacterial biomaterials," Artifical Organs (Japan) 9(1), 267-270, (1980), (partial translation).
Issekutz: "Removal of Gran--negative Endotoxin from Solutions by Affinity Chromatography," J. of Immunological Methods, 61, pp. 275-280, (1983).
LaPorte et al: "Inhibition of Escherichia coli Growth and Respiration by Polymyxin B Covalently Attached to Agarose Beads," Biochemistry, 16, No. 8, 1642-1648, (1977).
Hanazawa Kazuyoshi
Kodama Masashi
Nishiumi Shiro
Oka Totaro
Tani Toru
Cintins Ivars
Toray Industries Inc.
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