Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-12-21
1995-01-17
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530329, A61K 3702, C07K 706
Patent
active
053825691
ABSTRACT:
Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
REFERENCES:
Doherty et al., J. of Cardiovascular Pharmacology, Structure-Active Studies of the C-Terminal Region of the Endothelins of Sarafotoxins pp. 559-561, Oct. 4, 1991.
Stewart, J. et al., Solid Phase Peptide Synthesis, Pierce Chemical Co. ,1984.
Chemical Abstracts, vol. 117, No. 13, Sep. 28, 1992, W. L. Cody, et al., J. Med. Chem. 1992, 35 (17), 3301-3303.
G. R. Pettit, "Synthetic Peptides", 1970, Van Nostrand Reinhold Company, p. 149.
1992 FASEB Meeting, Anaheim Calif., Apr. 5-9, 1992, 390, D. M. LaDouceur, et al.
Rovero, P., et al., British Journal of Pharmacology 101, pp. 232-234.
Doherty, A. M., et al., Abstract, Second International Conference on Endothelin, Dec. 9, 1990.
J. of Cardiovascular Pharmacology 17 (Suppl. 7) S59-S61, 1991, A. M. Doherty, et. al "Structure-Activity Studies of the C-Terminal Region of the Endothelins and the Sarafotoxins".
PCT International Search Report for Corresponding PCT Application No. PCT/US 92/03408 Filed Apr. 24, 1992.
J. Cardiovascular Pharmacology, (2nd International Conference on Endothelin, Tsukaba, Japan, 9-12, Dec. 1991, pp. S59-S61.
Biochemical & Biophysical Research Comm., vol. 163, No. 1, Aug. 30, 1989, K. Nakajima, pp. 424-429.
Cody Wayne L.
DePue Patricia
Doherty Annette M.
He John X.
Taylor Michael D.
Lee Lester L.
Tinney Francis J.
Warner-Lambert & Company
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