Endothelin receptor anatagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 84, 514 92, 514100, 514277, 514337, 514338, 514381, 514382, 514450, 514452, 514465, 514517, 514530, 514569, 558 52, 558198, 558275, 560 80, 560 56, 562 24, 562428, 562442, 562451, 562452, 562455, 562466, 549349, 549350, 549359, 549362, 549433, 549435, 549447, 549462, 549220, 549230, 548253, 546 22, 546256, 546267, 5462681, 5462824, 5462837, 546342, A61K 3136, A61K 3144, A61K 31335, A61K 3119, C07D31764, C07D31770

Patent

active

057191824

ABSTRACT:
Novel indane and indene derivatives are described which are endothelin receptor antagonists.

REFERENCES:
patent: 3642785 (1972-02-01), Shen et al.
patent: 3737455 (1973-06-01), Shen et al.
Yamamara et al., Bull. Chem. Soc. Japan, 59, 3699 (1986).
Komendantov et al., C.A., 88:190,677p (1978).
Ihara et al., Biochem & Biophys Res. Comm., 178(1), 132-137 (1991).
Miyata et al., Journal of Antibiotics, 45(7), 1041-1046 (1992).
Koelsch, J. Org. Chem, 25, 2088 (1960).

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