Endothelin B.sub.1, (ETB.sub.1) receptor polypeptide and its enc

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 691, 530350, 536 235, C12Q 100, C12N 1512, C07K 14705

Patent

active

057732230

ABSTRACT:
A new endothelin B receptor has been identified, and the amino acid and nucleotide sequence of the receptor are provided. The nucleotide sequence is useful to construct expression cassettes and vectors to produce host cells which are capable of expressing the receptor, its mutants, fragments, or fusions. Such polypeptides are useful for identifying new endothelin agonists and antagonists.

REFERENCES:
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Ogawa et al., BioChem. and Biophys. Res. Comm. (1991) 178:248-255.
Sakamoto et al., BioChem. and Biophys. Res. Comm. (1991) 178:656-663.
Mizuno et al., Biochem. J. (1992) 287:305-309.
Arai et al., J. of Biological Chem. (1993) 268:3463-3470.
Adachi et al., FEBS, vol. 311, p. 179, 1992.
Aramori et al., The Journal of Biological Chemistry, vol. 267, p. 12468, 1992.

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