Endothelin Antagonists II

Details Endothelin Antagonists II Endothelin Antagonists II

1994-06-30

1996-08-27

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 19, 514 20, 514297, 514437, 514454, 514561, 514564, 514567, 530329, 530330, 530331, 546104, 549 26, 549390, 562445, 562450, A61K 3804, A61K 3808, C07K 504, C07K 706

Patent

active

055501109

ABSTRACT:
Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders especially cerebral vasospasm, stroke, and head injury, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease, restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, and diabetes.

REFERENCES:
patent: 5264577 (1993-11-01), Beylin et al.
patent: 5382569 (1995-01-01), Cody et al.
patent: 5430022 (1995-07-01), Hemmi et al.
Copending U.S. Ser. No. 07/995,480 Filed: Dec. 21, 1992 U.S. Pat. No. (5,382,569).
International Search Report, PCT/US 95/04171 (completed 10 Jul. 1995).
208th ACS National Meeting, Aug. 1994, MEDI 218, He et al.
208th ACS National Meeting, Aug. 1994, MEDI 150, Cody et al.
Chemical Abstracts 72: 100435a (1970).
Eur. J. Pharm., vol. 252, No. 3, issued 1994, Battistini et al, "Comparison of PD 145065 and Ro 46-2005 as Antagonists . . . ", pp. 341-345.
Med. Chem. Res., vol. 3, issued 1993, Cody et al, "The Rational Design of a Highly Potent Combined ET.sub.A and ET.sub.B . . . ", pp. 154-162.
Copending U.S. Ser. No. 07/701,274 Filed: May 16, 1991.
Copending U.S. Ser. No. 07/809,746 Filed Dec. 18, 1991.
International Search Report--Corresponding PCT Application PCT/93/03658.
Tamiaki, H., et al vol. 1, 1991 pp. 817-822 J. Chem. Soc. Perkin Trans.--(See Attached Communication Explaining Relevance Of Reference).
J. Cardiovasc. Pharm. vol. 17, No. 7, 1991 pp. S59-S61, Doherty, A. M., et al. (Previously Cited).
J. Med. Chem., vol. 35, 1992, pp. 3301-3303 Cody, W. L, et al. (Published After Priority Date).

Affiliated with

Also associated with

Rating

Endothelin Antagonists II does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endothelin Antagonists II, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin Antagonists II will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1056226