Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-06-01
1998-03-24
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
5462791, 548125, 548132, 548253, 5482662, 5482666, 548412, 548413, 548517, 548518, 548525, 548526, 548531, 548541, 548543, 548544, 548556, 548557, 548566, 548567, 548570, 548571, 548572, 548577, C07D40514
Patent
active
057314349
ABSTRACT:
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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Tsuge, et al., Chemistry Letters, 801-804 (1984).
Tsuge, et al., Bull Chem. Soc. Jpn., 59:2537 (1986).
Bhagwat, S., "Synthesis of Enantiomerically Pure Pyrrolidinones as Endothelin Receptor Antagonists", Tetrahedron Letters, 37(27):4627-4630, 1986.
Winn, et al., "2,4-Diarylpyrrolidine-3-carboxylic Acids-Potent ET.sub.A Selective Endothelin Receptor Antagonists." 1. Discovery of A-127722, 1984.
CA 119: 258811 Preparation of . . . A2 antagonists, Lavielle et al, 1993.
CA74:41752t Conformation of . . . Piperidinols. Settimj et al., 1974.
Boyd Steven A.
Hutchins Charles W.
Jae Hwan-Soo
Kester Jeffrey A.
Sorensen Bryan K.
Abbott Laboratories
Crowley Steven R.
McKane Joseph
Ward Michael J.
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