Endothelin antagonists

Details Endothelin antagonists Endothelin antagonists

1992-09-14

1999-07-13

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

562445, 562433, C07K 506

Patent

active

059226811

ABSTRACT:
Antagonists of endothelin are described, as well as methods of using them and pharmaceutical compositions containing them. These compounds are useful in controlling hypertension, myocardial infarction, pulmonary hypertension, angina, metabolic, endocrinological, and neurological disorders, congestive heart failure, septic or endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, preeclampsia, and diabetes.

REFERENCES:
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J. Clin. Invest. 83:1762 (1989) Kon et al., "Glomerular Actions of Endothelin In Vivo".
J. Am. Soc. Nephrol. 1:76 (1990) Perico et al., "Endothelin Mediates the Renal Vasoconstriction . . . ".
Chem. Pharm. Bull. 39:1295 (1991) Koshi et al., "Inhibition of Endothelin (ET)-1 and ET-2 . . . ".
Clin. Exp. Pharmacol. Physiol. 17:691 (1990), Miyamori et al., "Systemic and Regional Effects . . . ".
J. Tokyo Women's Med. Coll. 61:951 (1991) Ohno, "Effects of Endothelin-Specific Antibodies . . . ".
Circulation 83:1808 (1991) Lerman et al., "Endothelin has Biological Actions at Pathophysiological . . . ".
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Hypertension 15:729 (1990) Mortenson et al., "Chronic Hypertension Produced by Infusion . . . ".
Nature 348:730 (1990) Arai et al.
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FASEB J. 6:A1005 (1992) Werber et al., "DPR-1 ASP-15 Endothelin-1 does not Antagonize Endothelin . . . ".
J. Med. Chem. 35:3301 (1992) Cody et al., "Design of a Functional Hexapeptide Antagonist . . . ".
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FASEB J. 6 (part 1, No. 4):390 (1992) LaDouceur et al. "Effects of the endothelin receptor antagonist . . . ".
Biochem. Biophys. Res. Commun. 178:132 (1991), Ihara et al., "An Endothelin Receptor (ET.sub.A) Antagonist . . . ".
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