Endothelin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514423, 514424, 514425, 514426, 514428, 514429, A61K 3140, C07D20708

Patent

active

057671443

ABSTRACT:
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

REFERENCES:
patent: 3342833 (1967-09-01), Fremery
patent: 4340715 (1982-07-01), Grounder et al.
Bhagwat, S., "Synthesis of Enantiomerically Pure Pyrrolidinones as Endothelin Receptor Antagonists", Tetrahedron Letters, 37(27):4627-4630, 1984.
Winn, et al., 2,4-Diarylpyrrolidine-3-carboxylic Acids-Potent ET.sub.A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722, 1986.
Tsuge, et al. Chemistry Letters 801-804 (1984).
Tsuge, et al. Bull. Chem. Soc. Jpn 59 2537 (1986).

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