Endothelin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 89, 514 91, 514316, 514317, 514319, 514320, 514321, 514322, 546192, 546195, 546196, 546197, 546198, 546199, 546208, 546209, 546210, 546215, 546225, 546227, 546229, 546236, 546237, 546242, 546243, 546244, 546245, 546246, 546247, 546248, 548112, 548129, 548132, 5482632, 548243, A61K 3144, C07D21108

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active

056229712

ABSTRACT:
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

REFERENCES:
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Tsuge, et al., Chemistry Letters, 801-804 (1984).
Tsuge, et al., Bull. Chem. Soc. Jpn., 59:2537 (1986).
CA 90:121571 [2] Benzopyrano (4, 3-c) pyridine derivatives. Santroch et al., 1979.
CA 94:174887a Antidepressant . . . -3-phenylpiperidines. Ehrgott et al., pp. 709, 1981.
CA 94:103132g Synthesis . . . agents. Rahman et al., p. 721, 1981.
CA 105:22628s Synthesis . . . glycolates. Banglun, p. 763, 1986.

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