Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1994-03-21
1995-08-22
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
546184, 548496, 562 30, A61K 3806
Patent
active
054441528
ABSTRACT:
Peptides having the formula ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.
REFERENCES:
patent: 3872074 (1975-03-01), Konig et al.
Biochemical and Biophysical Research Communications, vol. 156, No. 3, Nov. 15, 1988, pp. 1182-1186, S. Kimura, et al., "Structure-Activity Relationships of Endothelin: Importance of the C-Terminal Moiety".
Journal of the American Chemical Society, vol. 83, No. 1, Jan. 16, 1961, & Jan. 5, 1961, pp. 1, 145-149.
Bulletin of the Chemical Society of Japan, vol. 43, No. 4, Apr. 1970, pp. 1197-1202, S. Matsuura, et al., "Studies of Peptide Antibiotics. XVI. Analogs of Gramicidin S Containing Beta-Alanine in Place of L-Proline".
Fujita Kagari
Fukami Takehiro
Hayama Takashi
Ihara Masaki
Ikemoto Fumihiko
Banyu Pharmaceutical Co. Ltd.
Lukton David
Warden Jill
LandOfFree
Endothelin antagonistic peptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Endothelin antagonistic peptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin antagonistic peptide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2142621