Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-26
1997-11-25
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 530330, 530331, 530329, A61K 3800, C07K 706, C07K 508
Patent
active
056913150
ABSTRACT:
The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the treatment of hypertension, pulmonary hypertension, Reynaud's disease, myocardial infarction, angina pectoris, acute renal failure, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension.
REFERENCES:
patent: 5284828 (1994-02-01), Hemmi et al.
patent: 5352659 (1994-10-01), Wakimasu et al.
patent: 5382569 (1995-01-01), Cody et al.
patent: 5444152 (1995-08-01), Ishikawa et al.
patent: 5470833 (1995-11-01), Ishikawa et al.
Fujita Kagari
Fukami Takehiro
Hayama Takashi
Ihara Masaki
Ikemoto Fumihiko
Banyu Pharmaceutical Co. Ltd.
Marshall S. G.
Tsang Cecilia J.
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