Endothelin antagonist and/or endothelin synthase inhibitor in co

Details Endothelin antagonist and/or endothelin synthase inhibitor in co Endothelin antagonist and/or endothelin synthase inhibitor in co

1995-05-08

1998-09-22

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514548, 514565, 514899, A61K 3156, A61K 31225, A61K 31195

Patent

active

058114165

ABSTRACT:
A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal, treatment of atherosclerotic vascular disease and hypertension in males as well as females, and for hormone replacement therapy in peri- and post-menopausal females, comprising administering effective amounts of an endothelin antagonist and/or an endothelin synthase inhibitor or both, in combination with

REFERENCES:
patent: 5260276 (1993-11-01), Cody et al.
patent: 5378715 (1995-01-01), Stein et al.
patent: 5508045 (1996-04-01), Harrison et al.
Garfield et al., "Reversal of Preeclampsia Symptoms Induced in Rats by Nitric Oxide Inhibition With L-Arginine, Steroid Hormones and an Endothelin Antagonist," Soc. Gynecol. Invest. Abst. p. 384 (1994).
Chwalisz et al., "Estradiol Inhibits the Onapristone-Induced Preterm Parturition in Guinea Pigs by Blocking Cervical Ripening," J. Soc. Gynecol. Invest., vol. 2, No. 2, Mar. 1995.
Chwalisz et al., "Role of Progesterone During Pregnancy: Models of Parturition and Preeclampsia," Z. Geburtshilfe Perinatol, vol. 198, No. 5-5, pp. 170-180, 1994.
Richard et al., "In Vivo Evidence of an Endothelin-Induced Vasopressor Tone After Inhibition of Nitric Oxide Synthesis in Rats," Circulation, vol. 91, No. 3, pp. 771-775, Feb. 1995.
Yallampalli et al., Inhibition of Nitric Oxide Synthesis in Rats During Pregnancy Produces Signs Similar to Those of Preeclampsia, Am J Obstet. Gynecol, vol. 169, No. 5, pp. 1316-1320, 1993.
CA 121: 50830, Veniant et al., 1994.
CA 120: 271192, Cody et al, 1993.
CA 99: 169887, Szekenes-Bartho et al., 1983.

Affiliated with

Also associated with

Rating

Endothelin antagonist and/or endothelin synthase inhibitor in co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endothelin antagonist and/or endothelin synthase inhibitor in co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin antagonist and/or endothelin synthase inhibitor in co will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1621931