Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1993-02-25
1994-04-12
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
530351, 514 21, A61K 4505
Patent
active
053023846
ABSTRACT:
The present invention relates to intercellular adhesion inhibitory factors produced by cytokine activated endothelial cells. These factors designated endothelial-derived IL-8 find use in the diagnosis and treatment of inflammation and in the protection of endothelial cells from neutrophil mediated damage.
REFERENCES:
patent: 4571382 (1986-02-01), Adachi
patent: 4797277 (1989-01-01), Arfors
patent: 4840793 (1989-06-01), Todd, III et al.
patent: 4897348 (1990-01-01), Johnson et al.
BACHEM Biosciences, Inc., Lymphokine Bulletin Information Sheet, Feb. 1991 (BA 054).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule", Proc. Natl. Acad. Sci. USA 84:9238-9242 (Dec. 1987).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule (E-LAM 1) using monoclonal antibodies (Mab)", Fed. Proc. 46(3):405, Abstract No. 514 (Mar. 29-Apr. 2, 1987).
Bevilacqua et al., "Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines", J. Clin. Invest. 76:2003-2011 (Nov. 1985).
Bevilacqua et al., "Interleukin-1 activation of vascular endothelium-effects on procoagulant activity and leukocyte adhesion", Am. J. Pathol. 121(3): 394-403 (Dec. 1985).
Clore, G.M. et al., "Determination of the secondary structure of interleukin-8 by neclear magnetic resonance spectroscopy", J. of Biological Chemistry 264(32):18907-18911 (Nov. 15, 1989).
Dahinden, C. A. et al., "The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils", J. Exp. Med. 170:1787-1792 (Nov. 1989).
Denton, M. D. et al., "Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1", Am. J. Physiol. 261:F1071-F1079 (1991).
Furuta, R. et al., "Production and characterization of recombinant human neutrophil chemotactic factor", J. Biochem. 106:436-441 (1989).
Harlan, J. M., "Leukocyte-endothelial interactions", Blood 65(3):513-525 (Mar. 1985).
Korthuis, R. J. et al., "Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle", Am. J. Physiol. 254:H823-H827 (1988).
Kowalski, J. and Denhardt, D. T., "Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes", Molecular and Cellular Biol. 9(5):1946-1957 (May 1989).
Larsen, C. G. "Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor", Immunology 68:31-36 (1989).
Larsen, C. G. et al., "The neutophil-activating protein (NAP-1) is also chemotactic for T lymphocytes", Science 243:1464-1466 (Mar. 17, 1989).
Lee, T. H. et al., "Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts", Mol. Cell. Biol. 10:1982-1988 (1990).
Matsushima, K. et al., "Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor", J. Exp. Med. 167:1883-1893 (Jun. 1988).
Miller, H. I. et al., "Cloning and expression of a yeast ubiquitin-protein cleaving activity in Escherichia coli", Bio/Technology 7:698-704 (Jul. 1989).
Modi, W. S. et al., "Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily", Human Genetics 84:185-187 (1990).
Mukaida, N. et al., "Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8", J. of Immunology 143(4):1366-1371 (Aug. 15, 1989).
Mullenbach, G. T. et al., "Chemical systhesis and expression in yeast of a gene encoding connective tissue activating peptide-III", J. of Biological Chemistry 261(2):719-722 (Jan. 15, 1986).
Pober et al., "Activation of cultured human endothelial cells by recombinant lymphotoxin:Z comparison with tumor necrosis factor and interleukin 1 species", J. of Immunology 138:3319-3324 (May 15, 1987).
Pober, J. S. and Cotran, R. S., "The role of endothelial cells in inflammation", Transplantation 50(4):537-544 (Oct. 1990).
Schmid, J. and Weissmann, C., "Induction of mRNA for a serine protease and a .beta.-thromboglobulin-like protein in mitogen-stimulated human leukocytes", J. of Immunology 139(1):250-256 (Jul. 1, 1987).
Schroder, J. M., "The monocyte-derived neutrophil activating peptide (NAP/interleukin 8) stimulates human neutrophil arachdonate-5-lipoxygenase, but not the release of cellular arachidonate", J. Exp. Med. 170:847-863 (Sep. 1989).
Strieter, R. M. et al., "Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-.alpha., LPS, and IL-1.beta.", Science 243:1467-69 (Mar. 17, 1989.
Suzuki, K. et al., "Localization of chemotactic activity and 64 kD protein phosphorylation for human polymorphonuclear leukocytes in N-terminus of the chemotactic protein LUCT/IL-8#", Biochem. and Biophys. Res. Commun. 163(3):1298-1305 (Sep. 29, 1989).
Van Damme, J. et al., "Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of .beta.-thromboglobulin", Eur. J. Biochem. 181:337-344 (1989).
Van Damme, J. et al., "The chemotactic activity for granulocytes produced by virally infected fibroblasts is identical to monocyte-derived interleukin 8", Eur. J. Immunol. 19:1189-1194 (1989).
Van Damme, J. et al., "A novel, NH.sub.2 -terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity", J. Exp. Med. 167:1364-1376 (Apr. 1988).
Wheeler et al., Fed. Proc. 45:450, "Interleukin-1 treated endothelial cells produce an inhibitor of leukocyte-endothelial adhesion", Abstract No. 1725 (Feb. 21, 1986).
Wheeler et al., Fed. Proc. 46(3):758, "Characterization of an endothelial-derived inhibitor of leukocyte adhesion", Abstract No. 2577 (Feb. 24 or Mar. 1, 1987).
Willems, J. et al., "Human granulocyte chemotactic peptide (IL-8) as a specific neutrophil degranulator: comparison with other monokines", Immunology 67:540-542 (1989).
Tonnesen et al. (1986) Adv. Inflammation Res. 10:288-291.
McCord et al. (1986) Adv. Inflammation Res. 10:21-29.
Strieter et al. (1988, Nov. 15) Biochem Brophy Res Comm 156(3):1340;14 1345.
Zimmerman et al. (1985) J. Immunology 134(3):1866-1874.
Sofer et al. (1983) Biotechniques 1(4):198-203.
Wheeler et al. (1987, Mar. 1) Fed. Proc. 46(3):758.
Yoshimura et al. (Aug. 1, 1987) J. Immunology 139(3):788-793.
Schroder et al. (1987, Nov. 15) J. Immunology 139(10):3474-3483.
Gregory et al. (1988, Mar. 15) Biochem Biophys Res Comm 151(2):883-890.
Herbert et al. (1990) J. Immunology 145(9):3033-3040.
Lindley et al. (1988, Dec.) Proc. Natl. Acad. Sci. U.S.A. 85:9199-9203.
Walz et al. (1987, Dec. 16) Biochem. Biophys. Res. Comm. 149(2):755-761.
Yoshimura et al. (1987, Dec.) Proc. Natl. Acad. Sci. U.S.A. 84:9233-9237.
Wolpe et al. (1988, Feb.) J. Exp. Med. 167:570-581.
Hoover et al., J. Cell Biol. 95:10A (1982).
Basford et al., Blood 68:79a (1986).
Harlan et al., Blood 66:167-178 (1985).
Zimmerman et al., J. Immunol. 134:1866-1874 (1985)
Gimbrone, Jr. Michael A.
Wheeler M. Elyse
Brigham and Women's Hospital
Koh Choon P.
Wityshyn Michael G.
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