Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2007-02-13
2007-02-13
Lankford, Jr., Leon Blaine (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S325000, C435S366000
Reexamination Certificate
active
10287334
ABSTRACT:
A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general morphological and cell surface marker characteristics of endothelial cells. The ES derived endothelial cells also are capable of inducing and participating in blood vessel formation (or vascularization) when transplanted into tissue in vivo.
REFERENCES:
patent: 5691203 (1997-11-01), Katsuen et al.
patent: 5817773 (1998-10-01), Wilson et al.
patent: 5843780 (1998-12-01), Thomson
patent: 5879383 (1999-03-01), Bruchman et al.
patent: 6200806 (2001-03-01), Thomson
patent: 6632424 (2003-10-01), Lyman et al.
patent: WO 97/47734 (1997-12-01), None
Rathjen et al. Reprod Fertil. Dev. Oct. 1998 pp. 31-47.
U.S. Appl. No. 10/128,738, filed Oct. 23, 2003, Itescu.
U.S. Appl. No. 10/211,522, filed Oct. 16, 2003, Istkovitz-Eldor et al.
U.S. Appl. No. 10/348,359, filed Jan. 29, 2004, West.
Balconi, G, et al., “Development of Endothelial Cell Lines From Embryonic Stem Cells,” Arterioscler Thromb Vasc Biol., (2000) 20:1443-1451.
Carmeliet, P., “Mechanisms of Angiogenesis and Arteriogenesis,” Nature Medicine (2000) 6:389-395.
Choi, K, et al., “A Common Precursor for Hematopoietic and Endothelial Cells,” Development (1998) 125:725-732.
Cines, DB, et al., “Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders,” Blood (1998) 91:3527-3561.
Gehling UM, et al., “In vitro Differentiation of Endothelial Cells from AC133-positive Progenitor Cells,” Blood (2000) 95:3106-3112.
Hirashima, M, et al., “Maturation of Embryonic Stem Cells Into Endothelial Cells in an In Vitro Model of Vasculogenesis,” Blood (1999) 93:1253-1263.
Jackson, KA, et al., “Regeneration of Ischemic Cardiac Muscle and Vascular Endothelium by Adult Stem Cells,” The Journal of Clinical Investigation (2001) 107:1395-1402.
Kalka, C, et al., “Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization,” PNAS (2000) 97:3422-3427.
Levenberg, S, “Endothelial cells derived from human embryonic stem cells,” PNAS (2002) 99:4391-4396.
Yamashita, J, et al., “Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors,” Nature (2000) 408:92-96.
Papadimitriou, E., et al., “Endothelial Cell Proliferation Induced by HARP: Implication of N or C Terminal Peptides,” Biochem. and Biophys. Res. Comm. 274:242-248 (2000).
Auerbach Robert
Kaufman Dan S.
Lewis Rachel
Lankford, Jr. Leon Blaine
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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