Endothelial cell procurement and deposition kit

Surgery – Means and methods for collecting body fluids or waste material – Aspiration collection container or trap

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604320, A61J 100, A61M 100

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053123808

ABSTRACT:
The invention is an endothelial cell procurement and deposition kit for collecting fat from a patient, processing said fat to produce an endothelial cell deposition product, and depositing said product on the surface of a graft, all under sterile conditions established and maintained within the components of said kit comprised of: fat collection means for collecting subcutaneous fat from a patient; digestion means connectable to said fat collection means to maintain sterility during reception of said fat and for retaining said fat under sterile conditions during rinsing and digestion to produce a digested product; endothelial cell isolation means connectable to said digestion means for maintaining sterile conditions during reception of said digested product and for separating and isolating microvessel endothelial cells from said digested product to produce an endothelial cell product; cell deposition means connectable to said isolation means for maintaining sterile conditions during reception of said endothelial cell product and for depositing said cells on the surface of a graft to be implanted in a patient and facilitating implantation of said endothelial graft into a patient.

REFERENCES:
patent: 3191600 (1965-06-01), Everett
patent: 4511653 (1985-04-01), Play et al.
patent: 4621055 (1986-11-01), Theurer
Jarrell et al. "Human Adult Endothelail Cell Growth in Culture", J. Vascular Surg., vol. 1, No. 6, pp. 757-764 Nov., 1984.
Herring et al. "A Single-Staged Technique for Seeding Vascular Grafts with Autogenous Endothelium" Surgery, 1978 84:498-504.
Graham et al. "Cultured Autogenous Endothelial Cell Seeding of Vascular Prosthetic Grafts" Surg Forum 30:204-206 (1979).
Graham et al. "Expanded Polytetrafluoroethylene Vascular Prostheses Seeded with Enzymatically Derived and Cultured Canine Endothelial Cells" Surgery 91:550-559 (1982).
Dilley et al. "Endothelial Seeding of Vascular Prostheses" Jaffe ed. Biology of Endothelial Cells, the Hauge: Martinus Nijhoff, 1984 pp. 401-411.
Berger et al. "Healing of Arterial Prostheses in Man It's Completeness" Ann. Surg 175:118-127 (1972).
Jaffe et al. "Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells" J. Clin. Invest. 55:2757-64 (1973).
Lewis "Endothelium in Tissue Culter" Am. J. Anat. 30:39-59 (1922).
Jaffe et al. "Culture of Human Endothelial Cells Derived from Umbilical Veins" J. Clin. Invest. 52:2745-56 (1973).
Glassberg et al. "Cultured Endothelial Cells Derived From Human Iliac Arteries" In Virtro 18:859-866 (1982).
Sharefkin et al. "Early Normalization of Platelet Survival by Endothelial Seeding of Dacron Arterial Prostheses in Dogs" Surgery 92:385-393 (1982).
Stanely et al. "Enhanced Patency of Small Diameter Externally Supported Dacron Iliofemoral Grafts Seeded with Endothelial Cells" Surgery 92:994-1005 (1982).
Watkins et al. "Adult Human Saphenous Vein Endothelial Cells: Assessment of Their Reproductive Capacity for Use In Endothelial Seeding of a Vascular Prostheses" J. Surg. Res. 36:588-596 (1984).
Fishman "Endothelium: A Distributed Organ of Diverse Capabilities" Annals of New York Academy of Sciences, pp. 1-8 (1982).
Sauvage et al. "Interspecies Healing of Porous Arterial Prostheses" Arch Surg. 109:698-705 (1974).
F. Hess et al. "The Endothelialization Process of a Fibrous Polyurethane Microvascular Prostheses After Implanation In The Abdominal Aorta of the Rat" Journal of Cardiovascular Surgery, vol. 24, No. 5, pp. 516-524 (Sep.-Oct. 1983).
W. K. Nicholas et al. "Increased Adherence of Vascular Endothelial Cells to Biomer Precoated With Extracellular Matrix" Trans. Am. Soc., Artif. Intern. Organs 28:208-212 (1981).
C. L. Ives et al. "The Importance of Cell Origin and Substrate in the Kinetics of Endothelial Cell Alignment in Response to Steady Flow" Trans. Am. Soc, Artif. Intern. Organs 29:269-274 (1983).
S. G. Eskin et al. "Behavior of Endothelial Cells Cultured on Silastic and Dacron Velour Under Flow Conditions In Vitro Implications for Prelining Vascular Grafts with Cells" Artifical Organs 7(1):31-37 (1983).
T. A. Belden et al. "Endothelial Cell Seeding of Small-Diameter Vascular Grafts" Trans. Am. Soc. Artif. Intern. Organs 28:173-177 (1982).
W. E. Burkel et al. "Fate of Knitted Dacron Velour Vascular Grafts Seeded With Enzyumatically Derived Autologous Canine Endothelium" Trans. Am. Soc. Artif. Intern. Organs 2:178-82 (1982).
Herring et al. "Seeding Arterial Prostheses With Vascular Endothelium" Ann. Surg. vol. 190, No. 1, pp. 84-90 (Jul. 1979).
A. Wesolow "The Healing of Arterial Prostheses: The State of the Art" Thorac. Cardiovasc. Suregon 30:196-208 (1982).
T. Ishihara et al. "Occurrence and Significance of Endethelial Cells in Implanted Porcine Bioprosthetic Valves" American Journal of Cardiology 48:443-454 (Sep. 1981).
Williams et al. "Micropinocytic Ingestion of Glycosylated Albumin by Isolated Microvessels: Possible Role in Pathogenesis of Diabetic Microangiopathy" Proc. Natl. Acad. Sci. USA vol. 78, No. 4, pp. 2392-2397 Apr. 1981.
Williams et al. "Regulation of Micropinocytosis in Capillary Endothelium by Multivalent Cations" Microvascular Research 21 175-182 (1981).
Williams et al. "Quantitative Determination of Deoxyribonucleic Acid from Cells Collected on Filters" Analytical Biochemistry 107:17-20 (1980).
Wagner et al. "Exclusion of Albumin from Vesicular Ingestion by Isolated Microvessels" Microvascular Research 19:127-130 (1980).
Williams et al. "Metabolic Studies on the Micropinocytic Process in Endothelial Cells" Microvascular Research 18:175-184 (1979).
Williams "Vesicular Transport of Proteins by Capillary Endothelium" Annals of the New York Academy of Sciences 457-467 (1983).
Williams et al. "Enhanced Vesicular Ingestion of Nonenzymatically Glucosylated Proteins by Capillary Endothelium" Microvascular Research 28:311-321 (1984).
Williams et al. "Endocytosis and Exocytosis of Protein in Capillary Endothelium" Journal of Cellular Physiology 120:157-162 (1984).
Williams et al. "Isolation and Characterization of Brain Endothelial Cells: Morphology and Enzyme Activity" Journal of Neurochemistry 35:374-381 (1980).
McDonagh et al. "The Preparation and Use of Fluorescent-Protein Conjugates for Microvascular Research" Microvascular Research 27:14-27 (1984).
Madri et al. "Capillary Endothelial Cell Cultures: Phenotypic Modulation by Matrix Components" Journal of Cell Biology vol. 97 Jul. 1983 pp. 153-165.
Williams et al. "Adult Human Endothelial Cell Compatability With Prosthetic Graft Material" Journal of Surgical Research 38:618-629 (1985).
Kern et al. "Isolation and Culture of Microvascular Endothelium from Human Adipose Tissue" J. Clin. Invest. 71:1822-1829 (Jun. 1983).
Van Wachem et al. "Interaction of Cultured Human Endothelial Cells with Polymeric Surfaces of Different Wettabilities" Biomaterials 6:403-408 (1985).
Azizkham et al. "Mast Cell Heparin Stimulates Migration of Capillary Endothelial Cells in Vitro" J. Exp. Med. vol. 152 Oct. 1980 pp. 931-944.
Roblin et al. "Cell Surface Changes Correlated with Density Dependent Growth Inhibition: Glycosaminoglycan Metabolism in 3T3, SV3T3, and Con A Selected Revertant Cells" Biochemistry vol. 14, No. 2 1975 pp. 347-357.
Yang et al. "The Effect of Heparin on Growth of Mammalian Cells in Vitro" (40290) Proceedings of the Soc. for Experimental Biology and Medicine 159:88-93 (1978).
Thornton et al. "Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation" Science 11 Nov. 1983, vol. 222, pp. 623-625.
Laterra et al. "Functions for Fibronectin, Hyaluronate and Heparin Proteoglycans in Substratum Adhesion of Fibroblasts" Extracellular Matrix pp. 197-207, 1982.
Maciaq et al, "Factors Which Stimulate the Growth of Human Umbilical Vein Endothelial Cells in Vitro", Jaffe, E. A. (ed.) Biology of endothelial cells. 1984 Martinus Nijohff, pp. 87-117.
Madri, "The Immunochemistry of Extracellular Matrix", Boca Raton, Fla., CRC Press, (1982), vol. 1:75-90.
Baker et al, "Endothelialization of Human Collagen Surface with Human Adult Endothelial Cells", American Journal of Surgery, 150:197-200 (Aug. 1985).
Williams et al,

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