Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-03-23
1994-11-22
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, C07K 1300
Patent
active
053670566
ABSTRACT:
DNA sequences encoding endothelial cell-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and 1b) essentially free of normally associated animal proteins are disclosed.
DNA sequences encoding molecules involved in leukocyte adhesion (MILAs), methods for producing such molecules and MILAs (including the specific molecule, CDX) essentially free of normally associated animal proteins are also disclosed. Antibody preparations which are reactive for MILAs and also disclosed.
Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells, and methods for detecting acute inflammation are disclosed.
REFERENCES:
patent: 5011778 (1991-04-01), Newman et al.
Arfors, K.-E., et al., "A Monoclonal Antibody to the Membrane Glycoprotein Complex CD18 Inhibits Polymorphonuclear Leukocyte Accumulation and Plasma Leakage In Vivo", Blood, 69, pp. 338-340 (1987).
Aruffo, A., and B. Seed, "Molecular Cloning of a CD28 cDNA by a High Efficiency COS Cell Expression System", Proc. Natl. Acad. Sci. USA, 84, pp. 8573-8577 (1987).
Becker, D., et al., "Prolifieration of Human Malignant Melanomas Is Inhibited by Antisense Oligodeoxynucleotides Targeted Against Basic Fibroblast Growth Factor", Embo J., 8, pp. 3685-3691 (1989).
Benchimol, S., et al., "Carcinoembryonic Antigen, a Human Tumor Marker, Functions as an Intercellular Adhesion Molecule", Cell, 57, pp. 327-334 (1989).
Bevilacqua, M. P., and M. A. Gimbrone, "Inducible Endothelial Functions in Inflammation and Coagulation", Seminars in Thrombosis and Hemostasis, 13, pp. 425-433 (1987).
Bevilacqua, M. P., et al., "Interleukin 1 Acts on Cultured Human Vascular Endothelium to Increase the Adhesion of Polymorphonuclear Leukocytes, Monocytes, and Related Leukocyte Cell Lines", J. Clin. Invest., 76, p. 2003 11 (1985).
Bevilacqua, M. P., et al., "Endothelial-Dependent Mechanisms of Leukocyte Adhesion: Regulation by Interleukin-1 and Tumor Necrosis Factor", in Leukocyte Emigration and Its Sequelae (S. Karger A.G., Switzerland 1987), pp. 79-93.
Bevilacqua, M. P., et al., "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule", Proc. Natl. Acad. Sci. USA, 84, pp. 9238-9242 (1987).
Bevilacqua, M. P., et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins", Science, 243, pp. 1160-1165 (1989).
Brenan, M. and C. R. Parish, "Intracellular Fluorescent Labelling of Cells for Analysis of Lymphocyte Migration", J. Immun. Meth., 74, pp. 31-38 (1984).
Capon, D. J., et al., "Designing CD4 Immunoadhesins for AIDS Therapy", Nature, 337, pp. 525-531 (1989).
Carlsson, R., and C. Glad, "Monoclonal Antibodies into the '90s", Bio/Technology, 7, pp. 567-73 (Jun. 1989).
Cate, R., et al., "Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells", Cell, 45, pp. 685-698 (1986).
Cech, T. R., "Ribozymes and Their Medical Implications", J. Amer. Med. Assn., 260, pp. 3030-3034 (1988).
Chang, S., et al., "Recombination Following Transformation of Escherichia coli by Heteroduplex Plasmid DNA Molecules", Gene, 29, pp. 255-261 (1984).
Cotran, R. S., et al., "Introduction and Detection of a Human Endothelial Activation Antigen In Vivo", J. Exp. Med., 164, pp. 661-666 (1986).
Cotran, R. S., and J. S. Pober, "Endothelial Activation: Its Role in Inflammatory and Immune Reactions", in Endothelial Cell Biology, Simionescu and Simionescu, Eds., (Plenum Press, New York 1988), pp. 335-347.
Dana, N., et al., "Mo1 Surface Glycoprotein: Structure, Function and Clinical Importance", Pathol. Immunopathol. Res., 5, pp. 371-383 (1986).
Davis, M. M., "Subtractive cDNA Hybridization and the T-Cell Receptor Genes", Handbook of Experimental Immunology In Four Volumes, 4th ed. Blackwell Scientific Publications, Oxford, England (1986), pp. 76.1-76.13.
Davis, M. M., et al., "Cell-Type-Specific cDNA Probes and the Murine I Region: The Localization and Orientation of A.alpha..sup.d ", Proc. Natl. Acad. Sci. USA, 81, pp. 2194-2198 (1984).
Devereux, J. et al., "A Comprehensive Set of Sequence Analysis Programs for the VAX", Nucl. Acids Res., 12, pp. 387-395 (1984).
Duguid, J. R., et al., "Isolation of cDNAs of Scrapie-Modulated RNAs by Subtractive Hybridization of a cDNA Library", Proc. Natl. Acad. Sci. USA, 85, pp. 5738-5742 (1988).
Dustin, M. L., and T. A. Springer, "Lymphocyte Function-Associated Antigen-1 (LFA-1) Interaction with Intercellular Adhesion Molecule 1 (ICAM1) Is One of at Least Three Mechanisms for Lymphocyte Adhesion to Cultured Endothelial Cells", J. Cell. Biol., 107, pp. 321-331 (1988).
Elices, M. J., et al., "VCAM-1 on Activated Endothelium Interacts with the Leukocyte Integrin VLA-4 at a Site Distinct from the VLA-4/Fibronectin Binding Site", Cell, 60, pp. 577-584 (1990).
Ellison, J. W., et al., "The Sequence of a Human Immunoglobulin C-gamma-1 Gene", Nucl. Acis Res., 10, pp. 4071-4079 (1982).
Feinberg, A. P., and B. Vogelstein, "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity", Anal. Biochem., 132, pp. 6-13 (1983).
Feinberg, A. P., and B. Vogelstein, "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity", Anal. Biochem., 137, pp. 266-267 (1984) (Addendum).
Fisher, R. A., et al., "HIV Infection Is Blocked In Vitro by Recombinant Soluble CD4", Nature, 331, pp. 76-78 (1988).
Gimbrone, M. A., "Culture of Vascular Endothelium", Prog. Hemostasis Thromb., 3, pp. 1-28 (1976).
Gimbrone, M. A., "Blood Vessels and the New Mediators of Inflammation", Lab. Invest., 46, pp. 454-455 (1982).
Goding, W., ed., Monoclonal Antibodies: Principles and Practice, Chapter 3, (Academic Press, New York, 1983).
Goldenberg, D. M., "Targeted Cancer Treatment," Immunology Today, 10, pp. 286-288 (1989).
Grau, G. E., et al., "Monoclonal Antibody Against Interferon .gamma. Can Prevent Experimental Cerebral Malaria and Its Associated Overproduction of Tumor Necrosis Factor", Proc. Natl. Acad. Sci. USA, 86, pp. 5572-5574 (1989).
Gubler, U., and Hoffman, B. J., "A Simple and Very Efficient Method for Generating cDNA Libraries", Gene, 25, pp. 263-269 (1983).
Hambor, J. E., et al., "Functional Consequences of Anti-Sense RNA-Mediated Inhibition of CD8 Surface Expression in a Human T Cell Clone", J. Exp. Med., 168, pp. 1237-1245 (1988).
Harlan, J. M., "Leukocyte-Endothelial Interactions", Blood, 65, pp. 513-525 (1985).
Harlan, J. M., "Neutrophil-Mediated Vascular Injury", Acta Med. Scand., Suppl., 715, pp. 123-129 (1987).
Harlan, J. M., et al., "The Role of Neutrophil Membrane Proteins in Neutrophil Emigration", in Leukocyte Emigration and Its Sequelae, H. Movat, ed. (S. Karger AG, Basel, Switzerland, 1987), pp. 94-104.
Haselhoff, J., and W. L., Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities", Nature, 334, pp. 585-591 (1988).
Hedrick, S. M., et al., "Isolation of cDNA Clones Encoding T Cell-Specific Membrane-Associated Proteins", Nature, 308, pp. 149-153 (1984).
Hemler, M. E., "Adhesion Protein Receptors on Hematopoietic Cells", Immunol. Today, 9, pp. 109-113 (1988).
Hemler, M. E., et al., "The VLA Protein Family (Characterization of Five Distinct Cell Surface Heterodimers Each with a Common 130,000 Molecular Weight Subunit)", J. Biol. Chem., 262, pp. 3300-3309 (1987).
Hemler, M. E., et al., "Characterization of the Cell Surface Heterodimer VLA-4 and Related Peptides", J. Biol. Chem., 262, pp. 11478-11485 (1987).
Hession, C., et al, "Endothelial Leukocyte Adhesion Molecule 1: Direct Expression Cloning and Functional Interactions", Proc. Natl. Acad. Sci. USA, 87, pp. 1673-1677 (1990).
Hirt, B., "Selective Extraction of Polyoma DNA from Infected Mouse Cell Cultures", J. Mol. Biol., 26, pp. 365-369 (1967).
Hough, A., and L. Sokoloff, "Pathology", Chap. 4, Rheumatoid Arthritis, P. D. Ustinger, N. J. Zugifler and G. E. Ehrlich, eds., (Lippencott, Philadelphia, 1985), pp. 49-69
Benjamin Christopher D.
Goelz Susan E.
Hession Catherine A.
Lobb Roy R.
Osborn Laurelee
Biogen Inc.
Carlson Karen Cochrane
Creason Gary L.
Haley, Jr. James F.
Hill Jr. Robert J.
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