Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2005-05-31
2005-05-31
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
C514S002600, C530S399000
Reexamination Certificate
active
06899882
ABSTRACT:
A novel growth factor specific for vascular endothelial cells has been identified in conditioned medium of bovine pituitary derived folliculo stellate cells. This factor, named folliculo stellate derived growth facto (FSdGF) or vascular endothelial growth factor (VEGF), was purified to homogeneity by a combination of heparin sepharose affinity chromatography, Bio Gel P-60 exclusion chromatography, Mono S ion exchange chromatography and hydrophobic chromatography on a C4 reverse phase HPLC column. The factor is also found in the murine AtT-20 cell line.
REFERENCES:
patent: 4456550 (1984-06-01), Dvorak et al.
patent: 4670394 (1987-06-01), Pollard et al.
patent: 4721672 (1988-01-01), Vallee et al.
patent: 4738927 (1988-04-01), Taniguchi et al.
patent: 4783412 (1988-11-01), Bell
patent: 4801542 (1989-01-01), Murray et al.
patent: 5008196 (1991-04-01), Connolly et al.
patent: 5073492 (1991-12-01), Chen et al.
patent: WO84/021 (1984-06-01), None
patent: 0370989 (1990-06-01), None
patent: WO9102058 (1991-02-01), None
Ferrara et al. Proc. Natl. Acad. Sci. USA 84, 5773-5777, 1987.*
Senger et al. (1983) Science 219, 983-985.*
Criscuolo et al. (1988) J. Neurosurg. 69, 254-262.*
D.W. Leung, Science, vol. 246, p. 1306, (Dec. 8, 1989).
P.J. Keck, et al.Science,vol. 246, p. 1309, (Dec. 8, 1989).
G.E. Lemke, et al.Journal of Neuroscience,vol. 4 No. 1, p. 75 (Jan. 1984).
N. Ferrara, et al.,Biochemical and Biophysical Research Communications,vol. 161, No. 2, p. 851 (Jun. 15, 1989).
D. Gospodarowicz, et al.Biochemistry,vol. 86 p. 882 (1989).
N. Ling, et al.Biochemistry,vol. 82, p. 7217 Nov. 1985).
N. Ueno, et al.,Biochemistryvol. 84, p. 8282 (Dec. 1987).
S. Shimasaki, et al.,Biochemical and Research Communications,vol. 152, p. 717, (Apr. 29, 1988).
D. M. Robertson et al.Biochemical Biophysical Research Communications,vol. 149, No. 2, p. 744 (Dec. 16, 1987).
D.R. Senger, et al.Cancer Research,vol. 46 p. 5629, (Nov. 1986).
D.T. Connolly, et al., J. Clinical Investigation, vol. 84 p. 1470 (Nov. 1989).
D.T. Connelly, et al.,Journal of Biological Chemistryvol. 264, #44, p. 20017 (1989).
F. Ishikawa, et al.,Nature,vol. 338 p. 557 (Apr. 1989).
J.S. Rubin, et al.Proc. Natl. Acad. Sci, U.S.A.,vol. 86 p. 802, (Feb. 1989).
Burgess et al. J. Biol. Chem. 260(21), p. 11389-11392, 1985.
Winkles et al. Proc. Natl. Acad. Sci. USA 84, p. 7124-7128, 1987.
Tashiro et al. Proc. Natl. Acad. Sci. USA 87, 3200-3204, 1990.
Gimencz-Gallego et al. BBRC. 138(2), 611-617, 1986.
Lobb et al. J. Biol. Chem. 261(4), 1924-1928, 1986.
G. Conn et al., “Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line”, Proc. Nat. Acad. Sci. USA, vol. 87 (1990), pp. 1323-1327.
G. Conn, Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous t platelet-derived growth factor:, Proc. Nat. Acad. Sci., vol. 87 (1990), pp. 2628-2632.
D.R. Senger et al., “Purification of NH2-Terminal Amino Acid Sequence of Guinea Pig Tumor-secreted Vascular Permeability Factor”, Cancer Res., vol. 50 (1990), pp. 1774-1778.
N. Ferrara et al., The Vascular Endothelial Growth Factor Family of Polypeptides,J. Cell Biochem.,vol. 47 (1991), pp. 211-218.
C. de Vries et al., “The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Fact r”, Science, vol. 255 (1992), pp. 989-991.
G. Beck et al., “Isolation and Characterization of a Vascular Permeability Factor from Stimulated U937 Cells”, J. Leukocyte Bio. vol. 42:5 (1987), p. 568.
J.N. Bruce et al., “Vascular Permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone”, J. Neurosurg., vol. 67 (1987), pp. 880-884.
G. Gospodarowicz et al., “Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells”, stellate cells, Proc. Nat. Acad. Sci., vol. 86 (1989), pp. 7311-7315.
J. Plouet et al., Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells, EMBO J., vol. 8:12 (1989), pp. 3801-3806.
Edmund Tischer et al., “Vascular Endothelial Growth Factor: A New Member of the Platelet-Derived Growth Factor Gene Family,” Biochemical & Biophysical Research Communications, vol. 165(3), pp. 1198-1206.
Ferrara Napoleone
Gospodarowicz Denis
Plouét Jean
Peters Howard M.
Peters Verny Jones Schmitt & Aston, LLP
Spector Lorraine
The Regents of the University of California
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