Endothelial cell expression patterns

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S130100

Reexamination Certificate

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10474794

ABSTRACT:
To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

REFERENCES:
patent: WO 02/10217 (2002-02-01), None
Jansen, M et al, 1995, Pediatric Res, 37 (6): 681-686.
Alberts et al. (Molecular Biology of the Cell, 3rd edition, 1994, p. 465.
Shantz and Pegg (Int J of Biochem and Cell Biol., 1999, vol. 31, pp. 107-122.
McClean and Hill (Eur J of Cancer, 1993, vol. 29A, pp. 2243-2248.
Fu et al (EMBO Journal, 1996, vol. 15, pp. 4392-4401.
Yokota, J et al (Oncogene, 1988,vol. 3, pp. 471-475.
Database GenCore AC AAB85394, WO 01/53500 A1 (HYSEQ Inc.) Jul. 26, 2001, see entire document.
Database GenCore ACQ96PD9, Kinzler, et al., “Cell Surface Tumor Endothelial Makers are Conserved in Mice and Humans”, Cancer Res., Sep. 2001, 6649-6655, vol. 61, No. 18. pp. 6649-6655.
St. Croix et al., “Genes Expressed in Human Tumor Endothelium,” Science, Aug. 18, 2000, vol. 289, No. 5482, pp. 1197-1202.

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