Endoscopic administration of an HSV-tk gene to treat digestive o

Details Endoscopic administration of an HSV-tk gene to treat digestive o Endoscopic administration of an HSV-tk gene to treat digestive o

1997-10-10

1999-12-07

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 932, 4353201, 600101, A61K 4800, C12N 500, C12N 1500

Patent

active

059983841

ABSTRACT:
A therapy for a disease, e.g., gastric cancer, comprising endoscopic local administration of a vector having a gene for treatment or cells producing the vector to a lesion to transduce the gene into target cells. The direct in vivo transduction of a gene for treatment into the affected site is expected to produce therapeutic effects specific on the lesion. Since the gene is introduced also into lymph nodes which may have developed a metastatic lesion, both the primary lesion and the metastatic lesion in the surrounding lymph nodes can be treated simultaneously.

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