Endorphins having placental or pancreatic origin

Details Endorphins having placental or pancreatic origin Endorphins having placental or pancreatic origin

1980-01-03

1982-02-23

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

260112R, 2601125R, A61K 3700, C07G 700, C07C10352, A61K 3702

Patent

active

043168957

ABSTRACT:
A peptide endorphin having a molecular weight in the range of about 4500 to 5000 daltons is described. This peptide endorphin has .beta.-endorphin-like activity, reacting immunologically to rabbit antisera prepared against .beta.-endorphin and displacing Naloxone from opiate receptors in brain tissue. Unlike .beta.-endorphin, however, this peptide endorphin does not exhibit respiratory depressor effect when administered to mice. This peptide endorphin can be obtained from placental and pancreatic tissue, preferably by extracting with dilute mineral acid.

REFERENCES:
patent: 3842063 (1974-10-01), Chance et al.
patent: 4038222 (1977-07-01), Li
patent: 4073885 (1978-02-01), Pert et al.
patent: 4098778 (1978-07-01), Li
patent: 4105651 (1978-08-01), Hughes
patent: 4116950 (1978-09-01), Li
Science vol. 207, 1980, pp. 78-80.
Chem. Abstr. vol. 90, 1979, p. 36766b.
Biol. Abstr. vol. 68, p. 27799.
Biol. Abstr. 67, p. 59719.
Biol. Abstr. 69, p. 22555.

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