Endophytic fungi from Pteromischum sp. plant, compounds...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...

Reexamination Certificate

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C530S300000, C530S350000, C530S820000, C530S823000, C514S003300

Reexamination Certificate

active

08080256

ABSTRACT:
The present disclosure relates to endophytic fungi from higher plants such as aPteromischumsp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.

REFERENCES:
patent: 6613738 (2003-09-01), Strobel
patent: 7232565 (2007-06-01), Henson et al.
patent: 2005/0260182 (2005-11-01), Strobel
Wang, et al. (2006) “Neoplaether, a New Cytotoxic and Antifungal Endophyte Metabolite from Neoplaconema Napellum IFB-E016” FEMS Microbiol. Lett 261, 218-223.
Ren, et al. (2008) “Colutellin A, an Immunosuppressive Peptide from Colletotriachum Dematium” Microbiology 154, 1973-1979.
Feng W. Wang et al. ‘Neoplaether, a new cytotoxic and antifungal endophyte metabolite fromNeoplaconema napellumIFB-E016.’ FEMS Microbiol Lett. vol. 261, No. 2, pp. 218-223 (Aug. 2006).
Yuhao Ren et al. ‘Colutellin A, an immunosuppressive peptide fromColletotriebum dematium,’ Microbiology, vol. 154, pp. 1973-1979 (Jul. 24, 2008).
International Search Report for PCT/US2008/082678, mailed Jun. 30, 2009.

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