Endophytic camptothecin and camptothecinoid producing fungi...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi

Reexamination Certificate

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C435S117000, C435S118000, C435S119000, C435S120000

Reexamination Certificate

active

07378268

ABSTRACT:
The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).

REFERENCES:
patent: 6180855 (2001-01-01), Hiruma et al.
patent: 6329193 (2001-12-01), Strobel et al.
patent: 6893668 (2005-05-01), Srivastava et al.
Liu Ji-Hua et al. “Isolation of endophytic fungi fromCamptotheca acuminateand the screening method of antitumor secondary metabolite produced by the fungi”. Journal of Plant Resources and Environment. Oct. 2004, vol. 13, No. 4, pp. 6-10.
Puri et al. “An endophytic fungus fromNothapodytes foetidathat produces camptothecin”. Journal of Natural Products. 2005. vol. 68, No. 12, pp. 1717-1719.

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