Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-10-09
2009-06-16
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07547715
ABSTRACT:
It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and/or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.
REFERENCES:
patent: 4479966 (1984-10-01), Hayashi et al.
patent: 169725 (1990-03-01), None
patent: 581187 (1996-12-01), None
patent: 860430 (1999-06-01), None
patent: 1121939 (2001-08-01), None
patent: 1175891 (2002-01-01), None
patent: 54-130543 (1979-10-01), None
patent: 2000-86517 (2000-03-01), None
patent: 2000-239188 (2000-09-01), None
patent: 2000-239188 (2000-09-01), None
patent: WO 99/09992 (1999-03-01), None
patent: WO 99/26629 (1999-06-01), None
patent: WO 00/03980 (2000-01-01), None
patent: WO 01/16132 (2001-03-01), None
patent: WO 01/72268 (2001-10-01), None
Hayashi, Jpn. J. Pharmacol, vol. 73, pp. 73-82, 1997.
Yoshitada Saki et al., “Prostaglandin E2 Regulates the Expression of Basic Fibroblast Growth Factor Messenger RNA in Normal Human Fibroblasts,” Kobe J. Med. Sci., vol. 47, No. 35/45, 2001, pp. 35 to 44.
Hiroshi Seno et al., “Cycloocygenase 2-and Prostaglandin E2Receptor EP2-dependent Angiogenesis in Apc716Mouse Intestinal Polyps,” Cancer Research, vol. 62, Jan. 15, 2002, pp. 506-511.
International Search Report dated Dec. 16, 2003.
R. Morishita et al., “Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor”, Diabetologia, vol. 40, pp. 1053-1061, 1997.
M. Majima et al., “Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants”, British Journal of Pharmacology, vol. 130, pp. 641-649, 2000.
Nishiura Akio
Ogata Teppei
Sakai Yoshiki
Ono Pharmaceutical Co. Ltd.
Seaman D. Margaret
Sughrue & Mion, PLLC
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