Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-09-11
1999-07-20
Ketter, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
43525233, 4353201, 530350, C12P 2106
Patent
active
059255412
ABSTRACT:
The present invention relates to purified and isolated nucleic acid encoding the endo-.beta.-galactosidase from Flavobacterium keratolyticus (referred to as "ENDO-A"), and to purified ENDO-A protein. The endo-.beta.-galactosidase of the invention may be used in a process which enzymatically de-antigenizes human erythrocytes bearing A.sub.1 antigen. The resulting erythrocytes may be transfused into individuals who would be otherwise unable to tolerate a transfusion of type A.sub.1 blood.
REFERENCES:
patent: 4609627 (1986-09-01), Goldstein
Fukuda, 1995, Current Protocols in Molecular Biology, Suppl. 32, John Wiley & Sons, .sctn..sctn. 17.17.6-17.17.13.
Zhu and Goldstein, 1993, Gene 137:309-314.
Amano et al., 1991, J. Biol. Chem. 266:11461-11477.
Goldstein, 1989, Transfusion Medicine Reviews (III)3:206-212.
Scudder et al., 1983, Biochem J. 213:485-494.
Fukuda, 1981, J. Biol. Chem. 256:3900-3905.
Kitamikado, 1981, J. Biol. Chem. 256:3906-3909.
Nakasawa and Suzuki, 1975, J. Biol. Chem. 250:912-917.
Hirano and Meyer, 1971, Biochem. Biophys. Res. Commun. 44:1371-1375.
Goldstein Jack
Leng Lin
Zhu Alex
Ketter James
New York Blood Center Inc.
Yucel Irem
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