Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-28
2006-03-28
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S465000, C514S466000, C549S440000, C549S441000, C549S444000, C549S445000, C549S447000
Reexamination Certificate
active
07019028
ABSTRACT:
The invention relates to compounds of the formula (I)process for their preparation starting from the plantBeilschmiedia fulva, PLA 101037, and the use thereof for producing a medicament, in particular for the treatment of allergic disorders, of asthmatic disorders, of inflammatory concomitant symptoms of asthma and/or of diseases which can be treated by inhibiting c-maf and NFAT.
REFERENCES:
Anuradha Ray et al., Th2 Cells and GATA-3 in Asthma: new insights into the Regulation of Airway Inflammation, The Journal of Clinical Investigation (1999, pp. 985-993, vol. 104, No. 8).
I-Cheng Ho et al., c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4-Dependent and -independent Mechanisms, J. Exp. Med. (1998, pp. 1859-1866, vol. 188, No. 10).
James E. Banfield et al., Constituents of Some Species of Beilschmiedia and Endiandra (Lauraceae): New Endiandric Acid and Benzopyran Derivatives Isolated from B. Oligandra, Aust. J. Chem. (1981, pp. 1655-1667, vol. 34).
James I. Kim et al., The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines, Immunity, (1999, pp. 745-751, vol. 10).
K. C. Nicolaou et al., The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 1. Stepwise, Stereocontrolled Total Synthesis of Endiandric Acids A and B, J. Am. Chem. Soc. (1982, pp. 5555-5557, vol. 104).
K. C. Nicolaou et al., The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis. 4. “Biomimetic” Approach to Endiandric Acids A-G. Total Synthesis and Thermal Studies, J. Am. Chem. Soc. (1982, pp. 5560-5562, vol. 104).
Paul S. Foster et al., Interleukin-5 and Eosinophils as Therapeutic Targets for Asthma, Trends in Molecular Medicine ( 2002, pp. 162-167, vol. 8, No. 4).
Wickramasinghe M. Bandaranayake et al., Constituents of Endiandra Species. I+ Endiandric Acid, a Novel Carboxylic Acid from Endiandra introrsa (Lauraceae), and a Derived Lactone, Aust. J. Chem. (1981, pp. 1655-1657, vol. 34).
Eder Claudia
Haag-Richter Sabine
Kogler Herbert
Aventis Pharma Deutschland GmbH
Aventis Pharmaceuticals Inc.
Desai Rita
Strupczewski Joseph
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