Endermic medicament with a gel base

Details Endermic medicament with a gel base Endermic medicament with a gel base

1990-10-29

1992-02-04

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carbohydrate or lignin, or derivative

514786, 514944, 514946, 514947, A61K 4700

Patent

active

050860771

ABSTRACT:
A novel endermic medicament having a consistency of a gel is proposed which is formulated, as a gel base, with non-ionic water-soluble cellulose ether, e.g., methyl cellulose and hydroxypropyl methyl cellulose, modified with a modification agent containing, in the molecule, an alkyl group having 6 to 26 carbon atoms and a functional group having reactivity with the hydroxyl group in the cellulose ether, e.g., stearyl glycidyl ether, decyl glycidyl ether and cetyl epoxide. The endermic medicament formulated with the modified cellulose ether is stable by virtue of the very little interaction between the active ingredients and the gel base and also can exhibit high percutaneous absorptivity of the active ingredients through the human skin.

REFERENCES:
patent: 4543258 (1985-09-01), Urata et al.
patent: 4832943 (1989-05-01), Grollier et al.
Technical Publication, Shin-Etsu Chemical Co., Ltd., Tokyo, "Metolose", pp. 1-17 (1977).
Chemical Abstracts 101:210861m (1984).

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