Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Utility Patent
1999-05-05
2001-01-02
Jarvis, William R. A. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C424S401000, C424S489000, C424S499000, C424S067000
Utility Patent
active
06169114
ABSTRACT:
FIELD OF THE INVENTION
This invention relates in general to an endermic liniment, and more particularly to an endermic liniment which can contain a thiol compound in a stable manner.
BACKGROUND OF THE INVENTION
A thiol compound is generally very unstable when exposed to light, heat, and oxygen, and therefore an endermic liniment which contains a thiol compound has the shortcoming of being easily oxidized by light, heat, or oxygen and thus losing its medicinal efficacy. Such compounds therefore must be stored in a cool, light free place or an airtight, sealed container, and its appication forms are significantly limited.
Also, the original thiol compound generally has a unpleasant odor and, when it is dissolved in an aqueous solution, produces a significantly offensive odor derived from sulfur, which limits the amount that can be blended into the endermic liniment.
Therefore, when blending a thiol compound in an endermic liniment, it was necessary to prevent the decomposition of the thiol compound by using an expensive light blocking container, a container with low oxygen permeability, or a container with high sealing performance, or by preparing it at the time of use.
If, despite such countermeasures, decomposition cannot be prevented and the unpleasant odor occurs, then there are limitations such as having to lower the blend ratio.
Based on the above mentioned problems, the inventors conducted earnest research and discovered that the occurrence of unpleasant odor due to light, heat, oxidation, etc. can be prevented and thiol compounds can be blended in a stable manner by blending the thiol compounds together with zinc oxide in an endermic liniment, thus completing the present invention.
The object of the present invention is to provide an endermic liniment which can contain a thiol compound in a stable manner.
DISCLOSURE OF THE INVENTION
That is, the present invention provides an endermic liniment which characteristically contains a thiol compound and zinc oxide.
Also, the present invention provides the aforementioned endermic liniment wherein said thiol compound is one or more types of glutathione and its derivatives.
Furthermore, the present invention provides the aforementioned endermic liniment wherein said thiol compound is one or more types of cysteine and its derivatives.
Also, the present invention provides the aforementioned endermic liniment wherein the average particle size of said zinc oxide is 0.2 micrometers or less.
Furthermore, the present invention provides the aforementioned endermic liniment wherein the content of said thiol compound is 0.001-20.0 wt % of the total endermic liniment.
Also, the present invention provides the aforementioned endermic liniment wherein the content of said zinc oxide is 0.01-50.0 wt % of the total endermic liniment.
THE BEST MODES OF THE EMBODIMENTS
The configuration of the present invention is described below.
Examples of the thiol compound used in the present invention include glutathione, acetylized glutathione, glutathione hydrochloride, phosphate, and sulfate, cysteine, N-acetyl cysteine, cysteine hydrochloride, cysteine sulfate, and cysteine phosphate, which are cysteine containing amino acid derivatives, as well as mercapto acetic acid, mercapto propionic acid, ammonium thiolactate and monoethanolamine thiolactate.
The thiol compound to be blended into the endermic liniment is selected based on the application of the endermic liniment. In general, a thiol compound has a reducing action and therefore is used as an antioxidant. In terms of usability, safety, and the efficacy, the preferable are glutathione and its derivatives as well as cysteine and its derivatives, which are amino acid-type compounds. The most preferable are glutathione and N-acetyl cysteine.
The blend ratio of the thiol compound varies depending on the application of the endermic liniment, but the blend ratio range is usually 0.001-20.0 wt % of the total endermic liniment. The endermic liniment of the present invention exhibits the significant effect of the present invention when the blend ratio is 0.1 wt % or more, preferably 1 wt % or more.
Zinc oxide used in the present invention acts as a stabilizer of the thiol compound. Specific examples include zinc flower, fine particle zinc oxide and ultra fine particle zinc oxide.
For the zince oxide, powder, fine powder in particular, is preferable. The finer the powder, the higher the effect of stabilizing the thiol compound. Considering the usability, the average particle size of the zinc oxide is preferably 0.001-0.2 micrometers, and more preferably 0.00 5-0.1 micrometers. Examples of the commercial products include ultra-fine particle zinc oxide FINEX75, FINEX50, and FINEX25 (Sakai Chemical Industry Co., Ltd.).
Zinc oxide with a water repellent treatment on its surface can also be used in the present invention. Examples of the water repellent treatment include the myristic acid treatment, zinc myristate treatment, aluminum myristate treatment, palmitic acid treatment, dextrin palmitic acid treatment, zinc palmitate treatment, aluminum palmitate treatment, stearic acid treatment, dextrin stearic acid treatment, zinc stearate treatment, aluminum stearate treatment, and silicone treatment, etc.
The blend ratio of zinc oxide is preferably 0.01-50.0 wt %, more preferably 0.05-20 wt %, of the total endermic liniment. If it is less than 0.01 wt % then the effect of the present invention may not be exhibited sufficiently. If it is more than 50 wt % then there may be adverse effects on the stability of base agent.
In the present invention, the stability of the thiol compound improves if an antioxidant is blended in addition to the aforementioned essential ingredients. The antioxidants that can be blended in include BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisol), gallic esters and their derivatives, and NDGA (nordihydroguaiaretic acid), among which BHT and BHA are particularly preferable.
The blend ratio of the antioxidant in the endermic liniment depends on the blend ratios of the thiol compound and zinc oxide. Usually, 0.001-10.0 wt % of the total endermic liniment is preferable. A more preferable range is 0.01-2 wt %.
In the present invention, blending zinc oxide in an endermic liniment containing a thiol compound prevents the unpleasant smell from the thiol compound and allows the thiol compound to be stable. Therefore, the endermic liniment of the present invention prevents the unpleasant smell due to light, heat, oxygen, etc., and has improved stability. Because of this, there are the following advantages: light blocking containers, containers with low oxygen permeability, containers with high sealing performance, etc., which are conventionally necessary, are not required, and the blend ratio of the thiol compound can be selected based on the purpose.
The endermic liniment of the present invention can contain medicinally effective ingredients other than the aforementioned thiol compound such as humectants, whitening agents, antiinflammatories, activating agents, blood flow promoting agents, antiseborrheac agents, plant extracts, various vitamins, etc., as well as other ingredients which can normally be contained in an endermic liniment, within the range that doesn't affect the effect of the present invention.
“Endermic liniment” in the present invention refers to cosmetics, drugs, quasi-drugs, etc. which are applied on the epidermis. It can comprise a wide variety of formulations including an aqueous solution system, solubilized system, emulsified system, powder system, oil-liquid system, gel system, ointment system, aerozol system, water-oil two-phase system, and water-oil-powder three-phase system. In the basic cosmetic area, it can be utilized in the aforementioned various formulations in product forms such as cleansing agents, toilet water, emulsions, creams, gels, essences (cosmetic lotion), pack masks, etc. In the makeup cosmetic area, it can be widely utilized in product forms such as foundations. In the drug or quasi-drug area, it can be widely utilized in product forms such as various ointm
Hatao Masato
Iwai Ichiro
Naganuma Masako
Yagi Eiichiro
Yamaguchi Kenji
Jarvis William R. A.
Kim Vickie
Shiseido Company Ltd.
Townsend & Banta
LandOfFree
Endermic liniment containing a thiol compound and zinc oxide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Endermic liniment containing a thiol compound and zinc oxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endermic liniment containing a thiol compound and zinc oxide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2544420