End-modified poly(beta-amino esters) and uses thereof

Details End-modified poly(beta-amino esters) and uses thereof End-modified poly(beta-amino esters) and uses thereof

2007-07-20

2011-12-06

Fubara, Blessing (Department: 1613)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Monomer contains oxygen

C424S400000, C514S04400A, C526S312000

Reexamination Certificate

active

08071082

ABSTRACT:
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.

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