End labeled nucleotide probe

Details End labeled nucleotide probe End labeled nucleotide probe

1988-02-26

1992-01-21

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 27, 435 6, 435 91, A61K 3170, C07H 1512, C12Q 168, C12P 1934

Patent

active

050828304

ABSTRACT:
An oligo- or polynucleotide having at least one biotin directly or indirectly attached to each of the 5' and 3' end nucleotides thereof and a nucleic acid hybridization assay system for use therewith. The biotins are optionally attached through linkage groups that do not interfere with hybridization. The biotins can further serve to attach a biotinylated polymer.

REFERENCES:
patent: 4760017 (1988-07-01), McCormick
Chem. Absts. 110(11):91667b, 1989.
Agrawal et al., Nuc. Ac. Res. 14(15):6277-6245, 1986.
Kempe et al., Nuc. Ac. Res. 13(1):45-57, 1985.
Leary et al., PNAS 80:4045-4049, 1983.
Cook, et al., "Synthesis and Hybridization of a Series of Biotinylated Oligonucleotides", Nucleic Acids Research vol. 16, No. 9, (pp. 4079-4093) (1988).
Langer-Safter et al., PNAS 79:4381 (1982).
Langer et al., PNAS 78:6633 (1981).
Brakel et al., in Kingsbury et al. (Eds.) Rapid Detection and Identification of Infectious Agents, Academic Press, New York, pp. 235-243 (1985).
Riley et al., DNA 5:333 (1986).
Forster et al., Nuc. Ac. Res. 13:745 (1985).
Chollet et al., Nuc. Ac. Res. 13:1529 (1985).
Wachter et al., Nuc. Ac. Res. 14:7985 (1986).
Chu et al., DNA 4:327 (1985).
Bryan et al., DNA 3:124 (1984).
Murasugi et al. DNA 3:269 (1984).
Haralambidis, et al., Nucleic Acids Research 15(12):4857-4876 (1987).

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