Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-03-24
2009-10-20
Chunduru, Suryaprabha (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S024310, C536S024320, C536S024330
Reexamination Certificate
active
07604937
ABSTRACT:
The present invention is directed to methods, reagents, and kits for detecting the presence or absence of (or quantifying) target polynucleotide sequences in at least one sample using encoding and decoding reactions. When a particular target polynucleotide is present in a sample, a reaction product is formed in the encoding reaction that includes addressable primer portions. At least one label and at least one address primer is employed in the decoding amplification reaction thereby providing a detectable signal value depending upon whether a sequence is present or absent. In some embodiments universal bases and reduced libraries of probes can be employed for highly multiplexed analysis of target polynucleotides.
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Belli et al. Rapid detection of exon 1 NRAS gene mutations using universal heteroduplex generator technology. Human Mutation, vol. 21, pp. 132-137, 2003.
International Search Report and Written Opinion dated Nov. 17, 2005, issued in International Application No. PCT/US2005/009882, filed Mar. 24, 2005, 10 pages.
Lao Kai Qin
Reed Mark T.
Applied Biosystems LLC
Chunduru Suryaprabha
Sun-Hoffman Lin
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