Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1997-04-16
1999-12-07
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424455, A61K 950
Patent
active
059979003
ABSTRACT:
The present invention is drawn to a composition of matter comprising high viscosity sodium alginate, cellulose sulfate and a multi-component polycation. Additionally, the present invention provides methods for making capsules, measuring capsule permeability to immunologically-relevant proteins and treating disease in an animal using encapsulated cells.
Over one thousand combinations of polyanions and polycations were examined as polymer candidates suitable for encapsulation of living cells and thirty-three pairs were effective. The combination of sodium alginate, cellulose sulfate, poly(methylene-co-guanidine) hydrochloride, calcium chloride, and sodium chloride produced the most desirable results. Pancreatic islets encapsulated in this multicomponent capsule demonstrated glucose-stimulated insulin secretion in vitro and reversed diabetes without stimulating immune reaction in mice. The capsule formulation and system of the present invention allows independent adjustments of capsule size, wall thickness, mechanical strength and permeability, and offers distinct advantages for immunoisolating cells.
REFERENCES:
patent: 5011634 (1991-04-01), Pietsch et al.
Anikumar Amrutur V.
Brissova Marcela
Lacik Igor
Powers Alvin C.
Prokop Ales
Adler Benjamin Aaron
Kulkosky Peter F.
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