Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1980-12-23
1982-10-12
Rosen, Sam
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 16, 424 31, 424 32, 435 2, 435240, A61K 928, A61K 900
Patent
active
043538886
ABSTRACT:
Viable mammalian cells are encapsulated in a polymeric membrane to form microencapsulated beads ready for introduction into a host body. The polymeric membrane allows passage therethrough of cell substrates and secretions, but prevents passage of larger molecules such as proteinaceous antibodies. In this way viable cells secreting essential products such as pancreatic islet cells secreting insulin can be transplanted into a host, and be protected against the immune reactions of the antibodies of the host which would otherwise reject the foreign cells. The cells are encapsulated from suspension in a non-solvent such as PPG, by addition thereto of a solution of a polymer (e.g. an acrylic/methacrylic acid esters copolymer) in dimethylsulfoxide. The polymer precipitates onto the cells to encapsulate them, and the supernatants are removed.
REFERENCES:
patent: 3717551 (1973-02-01), Bizzini et al.
patent: 4036693 (1977-07-01), Levine et al.
patent: 4184922 (1980-01-01), Knazek et al.
Chang et al.--Canadian J. of Physiol. & Pharmacol., vol. 44, (1966), pp. 115-128, (particularly 128).
Jack et al.--Advances in Biochem. Engineering, vol. 5, (1977), pp. 125-143, (particularly pp. 125-128).
Klein et al.--European Cong. on Biotechnology 1st Proceedings, (1978), pp. 142 and 145-148.
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