Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1979-03-28
1982-10-05
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
3 1, 264 4, 424 34, 424 35, 424 94, 435 1, 435175, 435182, 435240, C12N 1110, C12N 1104, C12N 500
Patent
active
043528830
ABSTRACT:
A core material such as living tissue, individual cells, hormones, enzymes or antibodies is encapsulated in a semipermeable membrane that is permeable to small molecules for contact with the core material but is impermeable to potentially deleterious large molecules. Encapsulation may be carried out by suspending the core material in an aqueous medium containing a water soluble gum that can be reversibly gelled, forming the suspension into droplets, contacting the droplets with a solution of multivalent cations to gel the droplets as discrete, shape-retaining, water insoluble temporary capsules and cross-linking a surface layer of the temporary capsules to produce a semipermeable membrane around the capsules. Optionally the gel within the membrane may be reliquified by removing multivalent cations from the gel.
REFERENCES:
patent: 3522346 (1970-07-01), Chang
patent: 3725113 (1973-04-01), Chang
patent: 3730841 (1973-05-01), Forgione et al.
patent: 3733205 (1973-05-01), Shorers et al.
patent: 3827565 (1974-08-01), Matsumora
patent: 3860490 (1975-01-01), Guttag
Chang, T.M.S., Biomedical Applications of Immobilized Enzymes and Proteins, vol. I, Plenum Press, N.Y., 1977, (pp. 69-90 and 147-153).
Tze, et al., Implantable Artificial Endocrine Pancreas Unit Used to Restore Normoglycaemia in the Diabetic Rat, Nature, vol. 264, 1976, (pp. 466-467).
Damon Corporation
Naff David M.
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