Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1988-12-12
1991-12-31
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
436829, B01J 1302, A61K 952
Patent
active
050770560
ABSTRACT:
Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.
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Bally Marcel B.
Cullis Pieter R.
Hope Michael J.
Madden Thomas D.
Mayer Lawrence D.
Bloom Allen
Kurtz Catherine L.
Shah Mukund J.
The Liposome Company Inc.
Ward E. C.
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