Encapsulating biological active substances into erythrocytes

Details Encapsulating biological active substances into erythrocytes Encapsulating biological active substances into erythrocytes

1983-10-27

1987-03-24

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 2, 210645, 2103212, A61K 3518

Patent

active

046524495

ABSTRACT:
This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.

REFERENCES:
patent: 2461505 (1949-02-01), Daniel
patent: 3591493 (1971-07-01), Zeineh
patent: 4192869 (1980-03-01), Nicolau et al.
patent: 4241187 (1980-12-01), White
patent: 4289756 (1981-09-01), Zimmermann
patent: 4366176 (1982-12-01), Wetzel
patent: 4478824 (1984-10-01), Franco
Martin et al.-Harper's Review of Biochemistry-19th Edit. pp. 68, 163, 164, 167, 180, 182, 190, 214, 215, 217, 241, 252 & 255.
Ropars-Bellagio Symposium-1st Int. Conf. on Red Blood Cell Carriers (1984) pp. 33-43.

Affiliated with

Also associated with

Rating

Encapsulating biological active substances into erythrocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Encapsulating biological active substances into erythrocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Encapsulating biological active substances into erythrocytes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1353253