Encapsulated mouse cells transformed with avian retrovirus-bovin

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424438, 514 12, 435177, 435182, 604891, A61K 944, A01N 2510, C12N 1102, C12N 1104

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046860983

ABSTRACT:
Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone. The transformed mouse cells were encapsulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.

REFERENCES:
patent: 4391909 (1983-07-01), Lim
Hymer et al., Neuroendocrinology, 32:339-349 (1981).
Woychik et al., Nucleic Acids Research, 10:7197-7210 (1982).

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