Enantioselective synthesis of pyrrolidines substituted with...

Details Enantioselective synthesis of pyrrolidines substituted with... Enantioselective synthesis of pyrrolidines substituted with...

2011-05-31

2011-05-31

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S543000, C548S551000

Reexamination Certificate

active

07951961

ABSTRACT:
The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancerwherein Ar has the meaning as indicated in the claims.

REFERENCES:
patent: 6784167 (2004-08-01), Wood et al.
patent: WO 2004-004632 (2004-01-01), None
patent: WO 2007-148158 (2007-12-01), None
Barnes et al., J. Am. Chem. Soc., 2002, 124 (44), 13097-13105.
Ghosh et al., Tetrahedron: Asymmetry, (1998), vol. 9, p. 1-45.
Naik et al., Tetrahedron, vol. 44., No. 7, (1988) p. 2081-2086, Great Britain, XP002093909.

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