Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1995-03-08
1996-11-12
Burn, Brian M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564415, 564428, C07C20940
Patent
active
055741860
ABSTRACT:
There is disclosed a novel process for the enantioselective synthesis of chiral amino alcohols from keto oxime ethers, which are derived from cyclic ketones, via catalytic asymmetric reduction, employing oxazaborolidine-borane complex (OAB-BH.sub.3). In this catalytic reduction process two chiral centers are created in a single step with high levels of stereoselectivity.
REFERENCES:
Blaser, H.-U., Chem. Rev. (1992), 92, 935-952.
Kano, S., et al., Chem. Lett. (1987) 1531-1534.
Gmeiner, P., et al., Tetrahedron Lett. (1993) 34, 4325-4326.
Oppolzer, W. et al., J. Am. Chem. Soc. (1992), 14, 5900-5902.
Lohray, B. B., et al., Tetrahedron Lett. (1989), 30, 2623-2626.
Cho, B. T., et al., Tetrahedron Asymeetry (1992), 3, 341-342.
Fisher, G. B., et al., Tetrhedron lett.(1993), 34, 7693-7696.
Beardsley D. A., Tehrahedron Lett. (1994) 35, 1511-1514.
Boudreau Charles
Tillyer Richard D.
Tschaen David M.
Ayler Sylvia A.
Burn Brian M.
Daniel Mark R.
Merck & Co. , Inc.
LandOfFree
Enantioselective synthesis of cyclic amino alcohols does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enantioselective synthesis of cyclic amino alcohols, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enantioselective synthesis of cyclic amino alcohols will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-564027